Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.150.1-150.1
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- 2003
Apicidin-induced gelsolin expression via Spl sites is mediated by PKC signaling
- Eun, Dae-Wook (Lab. of Biochem. & Mol. Biol, College of Pharmacy, Sungkyunkwan University) ;
- Cho, Eun-Jung (College of Medicine, Konyang University) ;
- Lee, Hoi-Young (Department of Genetic Engineering, College of Life Sci. & Tech., Sungkyunkwan University) ;
- Hong, Sung-Youl (Department of Genetic Engineering, College of Life Sci. & Tech., Sungkyunkwan University) ;
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Han, Jeung-Whan
(Department of Genetic Engineering, College of Life Sci. & Tech., Sungkyunkwan University)
;
- Lee, Hyang-Woo (Department of Genetic Engineering, College of Life Sci. & Tech., Sungkyunkwan University)
- Published : 2003.10.01
Abstract
Gelsolin, a actin binding protein, has been demonstrated to be involved in controlling cell morphology, motility, signaling, and apoptosis. It's expression is frequently downregulated in cervix cancer and several types of different human cancers indicating the role of gesolin in suppression of tumorigenicity. Apicidin, a novel histone deacetylase inhibitor, has been shown to cause growth arrest and morphological change of cancer cells, resulting from the alternation of protein expression, such as
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