Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.149.3-150
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- 2003
Inhibitory effects of [6]-gingerol on phorbol ester-induced cox-2 expression in mouse skin: p38 mapk and p65/rela as possible molecular targets
- Kim, Sue-Oko (College of Pharmacy, Seuoul National University) ;
- Chun, Kyung-Soo (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
[6]-Gingerol, a major pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae) has a wide array of pharmacologic effects. Our previous studies have demonstrated that [6]-gingerol inhibits mouse skin tumor promotion and anchorage-independent growth of cultured mouse epidermal cells stimulated with epidermal growth factor. In this study, we have investigated the molecular mechanisms underlying anti-tumor promoting effects of ［6］-gingerol on mouse skin carcinogenesis. (omitted)
Keywords