대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.122.1-122.1
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- 2003
The Flavonoid Morin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats
- Shin, Dong-Soo (College of Pharmacy, Pusan National University) ;
- Lee, Hye-Eun (College of Mediciney, Pusan National University) ;
- Lee, Hee-Woo (College of Mediciney, Pusan National University) ;
- Shin, Ji-Young (College of Mediciney, Pusan National University) ;
-
Yoon, Sik
(College of Mediciney, Pusan National University)
;
-
Chung, Hae-Young
(College of Mediciney, Pusan National University)
;
- Moon, Jeon-Ok (College of Mediciney, Pusan National University)
- 발행 : 2003.10.01
초록
Morin, one of the major natural flavonoids has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the hepatoprotective effect of morin on the dimethylnitrosamine (DMN)-induced liver damage in rats. Oral administration of morin (10, 20mg/kg daily for 4 weeks) into the DMN-treated rats remarkably prevented the elevation of serum alanine transaminase, aspartate transaminase and alkaline phospatase, and bilirubin levels. Morin also increased serum protein level and reduced the hepatic level of malondialdehyde in DMN-treated rats. (omitted)
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