대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.92.1-92.1
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- 2003
Suppression of RelA/p65 Transactivation Activity by a Lignoid Manassantin isolated from Saururus chinensis
- Kim, Kyung-Sook (KRIBB) ;
- Lee, Jeong-Hyung (College of Pharmacy, Chungbuk National University) ;
- Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) ;
- Nam, Jeong-Beom (College of Pharmacy, Chungbuk National University) ;
- Lee, Jung-Joon (College of Pharmacy, Chungbuk National University)
- 발행 : 2003.10.01
초록
In our search for NF-kB inhibitors from natural resources, we have previously identified two structurally related dilignans, manassantin A and B as specific inhibitors of NF-kB activation from Saururus chinensis. However, their molecular mechanism of action remains unclear. We here demonstrate that manassantin A and B are potent inhibitors of NF-kB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-kB. These compounds significantly inhibited the induced expression of NF-kB reporter gene by LPS or TNF-a in a dose-dependent manner. (omitted)
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