Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.90.2-90.2
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- 2003
Induction of apoptosis and $\G_1$ arrest by LJ-331, a novel nucleoside analog,in human leukemia HL-60 cells
- Lee, Eun-Jin (College of Pharmacy Ewha Womans University) ;
- Shin, Dae-Hong (College of Pharmacy Ewha Womans University) ;
- Jeong, Nak-Shin (College of Pharmacy Ewha Womans University) ;
- Lee, Sang-Kook (College of Pharmacy Ewha Womans University)
- Published : 2003.10.01
Abstract
In a continuous effort to develop novel anticancer agents we newly synthesized and evaluated the antitumor activity of nucleoside analogues. One analogue, 4-[2-Chlor-6-(3-iodo-benzylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid methylamide (LJ-331), has been shown to exert a potent inhibition of human cancer cell growth in vitro including human lung (A549), stomach (SNU-638) and leukemia (HL-60) cancer cells. Following mechanism of action study revealed that LJ-331 induces cell cycle arrest at the G
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