대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.75.3-76
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- 2003
Mitogen-activated protein kinase signaling pathway mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced apoptosis in Jurkat T cells.
- Kwon, Myung-Ja (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
- Jeong, Kyu-Shik (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
- Choi, Eun-Jeong (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
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Lee, Byung-Ho
(Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University)
- 발행 : 2003.10.01
초록
The present study was performed to examine mitogen-activated protein kinase associated pathways in mediation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cell apoptosis in cultured Jurkat T cells. TCDD significantly decreased cell viability in a concentration-dependent manner (p<0.05 at 10-300 nM). TCDD (10 nM) also time-dependently decreased cell viability (p<0.05 at 12-48 h). c-Jun NH
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