대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.75.2-75.2
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- 2003
Comparison of conotoxin gvia and cilnidipine on nicotinic receptor stimulation-induced catecholamine release in the rat Adrenal Galnd
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Lim, Dong-Yoon
(Laboratory of Pharmacology, College of Medicine, Chosun University)
- 발행 : 2003.10.01
초록
The present study was designed to compare the effects of conotoxin GVIA, a selective blocker of N-type voltage-dependent calcium channels (VDCC) and cilnidipine, a blocker of both L- and N-type VDCC, on the secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused rat adrenal gland, and also to establish the mechanism of action. 1. The inhibition of the CA secretory response evoked by acetylcholine (5.32 x 10
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