Design, Synthesis, And In Vitro Evaluation of Apio Analogs of Neplanocin A and Aristeromycin

  • Lee, Jeong-Ah (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Yoo, Byul-Nae (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Moon, Hyung-Ryong (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Lee, Kang-Man (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Jeong, Lak-Shin (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University)
  • Published : 2003.04.01

Abstract

Apio nucleosides whose 4'-hydroxymethyl group moves to 3'-position exhibit interesting biological activity such as antitumor or antiviral activity. On the other hand, neplanocin A and aristeromycin are the representative of the carbocyclic nucleosides and have been recognized as potent inhibitors of S-adenosylhomocysteine hydrolase. Based on these findings. it was of great interest to design apio analogues of neplanocin A and aristeromycin. (omitted)

Keywords