Acute effects of 2-bromopropane and 1,2-dibromopropane on hepatotoxic and immunotoxic parameters

  • Kim, Nam-Hee (College of Pharmacy, Yeungnam University) ;
  • Hyun, Sun-Hee (Department of Food Science and Technology, College of Natural Resource, Yeungnam University) ;
  • Kim, Chun-Hwa (College of Pharmacy, Yeungnam University) ;
  • Lee, Sang-Kyu (College of Pharmacy, Yeungnam University) ;
  • Lee, Dong-Wook (College of Pharmacy, Yeungnam University) ;
  • Jeon, Tae-Won (College of Pharmacy, Yeungnam University) ;
  • Lee, Jae-Sung (Department of Food Science and Technology, College of Natural Resource, Yeungnam University) ;
  • Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
  • Chae, Whi-Gun (School of Medicine, Taegu Catholic University)
  • Published : 2003.04.01

Abstract

2-Bromopropane (2-BP) is a major component of the mixture of SPG-6AR and Solvent 5200 that is a substitute of chlorofluorocarbon. Many female workers exposed to 2-bromopropane in a Korean electronic company were found to have amenorrhea and male workers were diagnosed with oligospermia. In the present studies, immunotoxic effects of 2-BP and an analog, 1,2-dibromopropane (1 ,2-DBP), were investigated in female BALB/c mice. (omitted)

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