대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.185.1-185.1
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- 2003
Cadmium altered zinc homeostasis in the Neuronal Cell
- Ahn, Sung-Hee (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
- Jang, Bong-Ki (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
- Park, Jong-An (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
- Lee, Jong-Wha (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University)
- 발행 : 2003.04.01
초록
In this study, we investigated the effect of cadmium on genes expression related to zinc homeostasis in HT22 hippocampal neuron cell line by RT -PCR and western blotting technics. In the time-course effect, cadmium up-regulated the relative levels of MT -I and MT -II to~b-actin at 4 hr after treatment. These effects were consistent with MT -I/II protein contents by western blot analysis. But MT -III, a specific MT isoform in brain, was not affected by cadmium. (omitted)
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