대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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The Inhibitory Effect of Zinc on the Cadmium-Induced Apoptosis in Human Breast Cancer Cells

  • Oh, Ji-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
  • Lee, Su-Jung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Shin, Jae-Ho (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kang, Il-Hyun (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, In-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, An-Keun (College of Pharmacy, SookMyung Women′s University) ;
  • Han, Soon-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA)
  • 발행 : 2003.04.01
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초록

Zinc is known to have an inhibitory effect on apoptosis and an antioxidative effect scavenging reactive oxygen species (ROS) under oxidative stress. We studied the influence of zinc on cadmium-induced apoptosis especially associated with ROS in MCF-7 human breast carcinoma cell line. For the determination of appropriate experimental concentration and time, we excecuted MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay and DNA fragmentation assay. (omitted)

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