Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.188-188
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- 2003
Induction of Reactive Oxygen Species and Malignant Transformation by Tcdd Through Metabolic Formation of Catechol Estrogens
- Na, Hye-Kyung (College of Pharmacy, Seoul National University) ;
- Chen, Zhi-Hua (College of Pharmacy, Seoul National University) ;
- Kim, Jung-Hwan (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototype of halogenated aromatic hydrocarbons, is a persistent environmental contaminant and one of the most powerful tumor promoters. The molecular mechanism underlying induction of tumor promotion by TCDD has not been elucidated.(omitted)
Keywords
- TCDD;
- catechol estrogen;
- Reactive Oxygen Species;
- Human mammary epithelial cells;
- Neoplastic transformation