Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Analysis of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Gene Expression Profile in Hairless Mice Skin Using Pathway Specific cDNA Microarray

  • Ryeom, Tai-Kyung (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kang, Ho-Il (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kang, Mi-Kyung (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Eom, Mi-Ok (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Mi-Sun (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jee, Seung-Wan (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Ok-Hee (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2003.10.01
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Abstract

2,3,7,8-Tetrachlorodibenzo-$\rho$-dioxin (TCDD) displays high toxicity in animals and has been implicated in human carcinogenesis. Although the mechanisms of TCDD-induced carcinogenesis are poorly understood, it considered to be non-genotoxic and tumor promoter. In this study, we investigated the tumor promotion effect of TCDD on the two-stage skin chemical carcinogenesis using hairless mouse (SKH1).(omitted)

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