Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.168-168
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- 2003
New Hdac Inhibitor, In2001 Induces Apoptosis/Cell Cycle Arrest in the Human Breast Cancer Cells
- Min, Kyung-Nan (College of Pharmacy, Ewha Womans University) ;
- Joung, Ki-Eun (College of Pharmacy, Ewha Womans University) ;
- Cho, Min-jung (College of Pharmacy, Ewha Womans University) ;
- Kim, Dae-Ki (College of Pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- Published : 2003.10.01
Abstract
The acetylation of histone is one of the mechanisms involved in the regulation of gene expression and is tightly controlled by two core enzymes, histone acetyltransferase (HAT) and deacetylase (HDAC). There are several reports that imbalance of HAT and HDAC activity is associated with abnormal behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis.(omitted)