Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Pharmacogenomic Application for Gene Targeting and Molecular Characterization of a Nucleoside Transporter hCNT2 in Human Intestine

  • Shin, Ho-Chul (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Lee, Jong-Hwa (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Lee, Han-Ok (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Duxin Sun (Dept. Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor) ;
  • Gordon L. Amidon (Dept. Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor)
  • Published : 2003.10.01
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Abstract

We have cloned and functionally expressed a sodium dependent human nucleoside transporter, hCNT2, from a CNS cancer cell line U251. Our cDNA clone of hCNT2 had the same predicted amino acid sequence as the previously cloned hCNT2 transporter. Of the several cell lines studied, the best hCNT2 transport function was obtained when transiently expressed in U251 cells.(omitted)

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