Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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A Pharmacogenomic Study on Regional Dependent gene Expression and Drug Permeability in Rat Intestine

  • Shin, Ho-Chul (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Chung, Moon-Koo (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Han, Sang-Seop (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
  • Duxin Sun (Dept. of Pharmaceutical Sciences, University of Michigan) ;
  • Gordon L. Amidon (Dept. of Pharmaceutical Sciences, University of Michigan)
  • Published : 2003.10.01
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Abstract

RNA was isolated from mucosal tissue of the duodenum, jejunum, ileum and colon after perfusion. The gene expression profiles were measured using Affymetrix GeneChip(R) analysis. Prodrug valacyclovir permeability was 5-fold and 2-fold higher than the parent drug acyclovir in the jejunum and ileum, respectively.(omitted)

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