Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
- /
- Pages.136-136
- /
- 2003
Regulation of Cyp 1A1 Gene Expression by Retinoic Acid Receptor, Retinoid X Receptor and Constitutive Androstane Receptor in Rainbow Trout Hepatoma Cells(Rth 149)
- Kim, Ji-Sun (College of Pharmacy, Ewha womans University) ;
- Yang, So-Yeun (College of Pharmacy, Ewha womans University) ;
- Seo, Mi-Jung (College of Pharmacy, Ewha womans University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha womans University)
- Published : 2003.10.01
Abstract
Exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a variety of biological and toxicology effects, most of which are mediated by aryl hydrocarbon receptor (AhR). The ligand-bound AhR as a heterodimer with AhR nuclear translocator (ARNT) binds to its specific DNA recognition site, the dioxin-responsive element (DRE), and it results in increased transcription of CVP1A1 gene.(omitted)