Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Oxidative DNA damage and its repair enzyme expression induced by welding fume inhalation.

  • Kim, Soo-Jin (Center for Occupational Toxicology, Chungnam National University) ;
  • Paik, Sang-Gi (Department of Biology, Chungnam National University) ;
  • Yu, Il-Je (Center for Occupational Toxicology, Chungnam National University) ;
  • Oky Maeng (Department of Biology, Chungnam National University) ;
  • Hyun, Jin-Suk (Center for Occupational Toxicology, Chungnam National University) ;
  • Sung, Jae-Hyuk (Center for Occupational Toxicology, Chungnam National University) ;
  • Han, Jeong-Hee (Center for Occupational Toxicology, Chungnam National University) ;
  • Maeng, Seung-Hee (Center for Occupational Toxicology, Chungnam National University)
  • Published : 2003.10.01
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Abstract

Welding fume (WF) induces pulmonary disease including pneumoconiosis. To investigate whether reactive oxygen species-induced oxidative DNA damage occurs during welding fume exposure and the upregulation of DNA repair mechanisms is accompanied, SPF SD rats were exposed to welding fumes with the concentrations of 65.6${\pm}$2.9 mg/㎥(low dose) and 116.8${\pm}$3.9 mg/㎥ (high dose) of total suspended particulate for 2 hrs per day in an inhalation chamber for a total of 2hrs, 15 or 30 days.(omitted)

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