Neurotoxicity of Halogenated Aromatic Hydrocarbons; Structure-Activity Relationship

  • Yang, Jae-Ho (Department of Pharmacology/Toxicology, Catholic University of Daegu, School of Medicine) ;
  • Kim, Sun-Young (Department of Pharmacology/Toxicology, Catholic University of Daegu, School of Medicine) ;
  • Lee, Ji-Hye (Department of Pharmacology/Toxicology, Catholic University of Daegu, School of Medicine) ;
  • Lee, Hyun-Gyo (Department of Pharmacology/Toxicology, Catholic University of Daegu, School of Medicine) ;
  • Kim, Mi-Young (Department of Pharmacology/Toxicology, Catholic University of Daegu, School of Medicine)
  • Published : 2003.10.01

Abstract

Halogenated aromatic hydrocarbons (HAHs) including TCDD and PCBs are known to cause neurotoxic effects in both man and animals such as cognitive impairment and motor dysfunctions. While theses chemicals may lead to neurodevelopmental and neurobehavioral deficit, structural activity relationship and molecular targets for these chemicals are not elucidated.(omitted)

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