Risk Assessment Diethylhexyl phthalate released from PVC Medical Devices based on Reproductive Toxicity

  • Lee, H-M (Risk Assessment Division, National Institute of Toxicological Research) ;
  • Yoon, E-K (Risk Assessment Division, National Institute of Toxicological Researc) ;
  • Lee, G-Y (Risk Assessment Division, National Institute of Toxicological Researc) ;
  • Kim, H-J (Risk Assessment Division, National Institute of Toxicological Researc) ;
  • Yang, J-S (Risk Assessment Division, National Institute of Toxicological Researc) ;
  • Yang, K-H (Risk Assessment Division, National Institute of Toxicological Researc) ;
  • Han, S-Y (Endocrine Toxicology Division, National Institute of Toxicological Researc) ;
  • Jang, S-Y (Medicinal Chemistry Division, Korea Food and Drug Administratio) ;
  • Choi, D-W (Medicinal Chemistry Division, Korea Food and Drug Administration)
  • Published : 2003.05.01

Abstract

Diethylhexyl phthalate (DEHP) was known as endocrine disrupter revealing reproductive / developmental toxicity. For a long time, risk due to DEHP released from PVC medical devices was became an issue for patient receiving blood bag, iv injection solution like saline and Hartman's solution. This study was conducted to suggest permissible intake level (PIL) of DEHP based on reproductive toxicity, to quantify daily intake level of DEHP can be exposed to patient through various medical treatment and to estimate risk values of DEHP released from PVC medical devices.(omitted)

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