대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.406.3-407
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- 2002
Analysis of Branched PEG-Conjugated Interferon Alpha by Capillary Electrophoresis and MALDI- TOF Mass Spectrometry
- Na, Dong-Hee (Drug Targetion Laboratory, College of Pharmacy. SungKyunKwan University) ;
- Park, Eun-Ji (Research Laboratories Dong-A Pharm. Co., Ltd) ;
- Lee, Snag-Deuk (Research Laboratories Dong-A Pharm. Co., Ltd) ;
- Jo, Young-Woo (Research Laboratories Dong-A Pharm. Co., Ltd) ;
- Lee, Sung-Hee (Research Laboratories Dong-A Pharm. Co., Ltd) ;
- Kim, Won-Bae (Research Laboratories Dong-A Pharm. Co., Ltd) ;
- Lee, Kang-Choon (Research Laboratories Dong-A Pharm. Co., Ltd.)
- 발행 : 2002.10.01
초록
Analysis of interferon alpha (IFN) modified with high molecular weight branched PEG was performed by capillary electrophoresis (CE) and MALDI-TOF mass spectrometry (MALDI-TOF MS). IFN was modified by the reaction of amine residues with an active ester of monomethoxy polyethylene glycol at various molar ratios. As a CE method. capilary electrophoresis sodium dodecyl sulfate nongel sieving (CE-SDS NGS) was performed using an uncoated capilary filled with a hydrophilic replaceable polymer network matrix. (omitted)
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