Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.325.3-326
- /
- 2002
Retrovirus-mediated Delivery of TIMP-2 Inhibits Migration. Invasion and Angiogenesis
- Ahn, Seong-Min (College of Pharmacy, Duksung Women′s University) ;
- Sohn, Yeo-Won (KFD) ;
- Kim, Yun-Soo (KRIB) ;
- Moon , A-Ree (College of Pharmacy, Duksung Women′s University)
- Published : 2002.10.01
Abstract
An imbalance between matrix metalloproteinase (MMP)-2 and its endogenous inhibitor. tissue inhibitor of metalloproteinase (TIMP)-2 causes the degradation of the extracellular matrix associated with pathological events including invasion. metastasis and angiogenesis. Since TIMPs are secreted molecules. they have the potential to be used for gene therapy of certain tumors. (omitted)
Keywords