Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Epigallocatechin Gallate inhibits Prostagladins Generation by Suppression of cPLA2 Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells

  • Son, Dong-Ju (College of Natural Sciences, Soonchunhyang University) ;
  • Akiba, Satoshi (Department of Pathological Biochemistry, Kyoto Pharmaceutical University) ;
  • Sato, Takashi (Department of Pathological Biochemistry, Kyoto Pharmaceutical University) ;
  • Park, Young-Hyun (College of Natural Sciences, Soonchunhyang University) ;
  • Yun, Yeo-Pyo (College of Pharmacy, Chungbuk National University)
  • Published : 2002.10.01
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Abstract

Green tea contains several antioxidants including polyphenols of the catechin. which have been shown to act in vitro and in vivo as anti-inflammatory. anti-viral and anti-tumor drugs. Prostaglandins (PGs) are a family of intercellular and intracellular messengers derived from arachidonic acid(AA) by phospholipase(PL) and cyclooxygenase(COX). These mediators exert a wide range of effects on processes such as smooth muscle tone. vascular permeability, cellular proliferation. and inflammatory/immune function. (omitted)

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