대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.251.3-252
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- 2002
Selectivity of the optical isomers of KR30031 on MDR reversal activity and cardiotoxicity
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Lee, Byung-Ho
(Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
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Lee, Chong-Ock
(Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
- Kwon, Myung-Ja (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
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Yi, Kyu-Yang
(Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
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Yoo, Sung-Eun
(Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
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Choi, Sang-Un
(Medicinal Science Division, Korea Research Institute of Chemical Technology)
- 발행 : 2002.10.01
초록
The present study was performed to compare the cardiovascular adverse effects of verapamil. KR30031 and their each optical isomers, and also to measure their ability to overcome multidrug resistance (MDR). R-isomer of KR30031 (R-KR30031) was equipotent with S-isomer of KR30031 (S-KR30031) and 25 fold less potent than R-isomer of verapamil (R-verapamil) in relaxing the aorta isolated from rat (EC50: 11.8, 10.2 and 0.46
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