대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.251.2-251.2
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- 2002
IN VIVO METABOLISM OF 2-METHYLAMINOETHYL-4,4'-DIMETHOXY-5,6,5',6'-DIMETHYLENEDIOXYBIPHENYL-2'-CARBOXY-2-CARBOXYLATE (DDB-S) BY LC/ESI TANDEM MASS SPECTROMETRY
- Son, Jung-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
- Lee, Jae-Ick (Department of Biotechnology, Yonsei University) ;
- Yang, Ryung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
- Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
- 발행 : 2002.10.01
초록
2-Methylaminoethyl- 4,4' -dimethoxy- 5, 5',6,6' -dimethylenedioxybiphenyl- 2' -carboxy- 2-carboxylate (DDB-S) is a synthetic compound derived from DDB. which is protects liver against carbon tetrachloride-, D-galactosamine-, thioacetamine-, and prednisolone- induced hepatic injury in experimental animals. We assessed the use of liquid chromatography/electrospray iontrap tandem mass spectrometry (LC/MS/MS) method to identify and quantify in vivo metabolites and to measure excretion. (omitted)
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