대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.232.2-232.2
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- 2002
Dexamethasone 21-sulfate sodium : A potential colon-specific prodrug of dexamethasone.
- Kim, In-Ho (College of pharmacy. Pusan National University) ;
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Jung, Yun-Jin
(College of pharmacy. Pusan National University) ;
- Doh, Min-Ju (College of pharmacy. Pusan National University) ;
- Kong, Hye-Sik (College of pharmacy. Pusan National University) ;
- Kim, Young-Mi (College of pharmacy. Pusan National University)
- 발행 : 2002.10.01
초록
Corticosteroids have been used most frequently for inflammatory bowel disease. They are well absorbed and only a limited fraction of the dose is delivered to the inflammatory site in the colon. To reduce side effects by the systemic absorption. colon-specific delivery is highly desirable. We designed dexamethasone 21-sulfate sodium (DS) as a cOlon-specific prodrug of dexamethasone (D) expecting that it might be stable and non absorbable in the upper intestine and dissociate in the colon by the sulfatase, an enzyme solely found in the colon. (omitted)
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