Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.191-192
- /
- 2002
A Novel and Highly Potent Non-vanilloid VR Antagonist
-
Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Lee, Yong-Sil (College of Pharmacy, Seoul National University) ;
- Min, Kyung-Hoon (College of Pharmacy, Seoul National University) ;
- Shin, Dong-Yun (College of Pharmacy, Seoul National University) ;
- Park, Ok-Hui (College of Pharmacy, Seoul National University) ;
- Kim, Jin-Kwan (College of Pharmacy, Seoul National University) ;
- Kim, Hee-Doo (College of Pharmacy, Sookmyung Women′s University) ;
- Park, Hyoung-Geun (College of Pharmacy, Seoul National University) ;
- Lee, Jee-Woo (College of Pharmacy, Seoul National University) ;
- Oh, Uh-Taek (Sensory Research Center,CRI,Seoul National University) ;
- Koo, Jea-Yeon (Sensory Research Center,CRI,Seoul National University) ;
- Park, Young-Ho (R&D Center of AmorePacific Corp.) ;
- Joo, Yung-Hyup (R&D Center of AmorePacific Corp.) ;
- Choi, Jin-Kyu (R&D Center of AmorePacific Corp.) ;
-
Jeong, Yeon-Su
(R&D Center of AmorePacific Corp.)
;
- Koh, Hyun-Ju (R&D Center of AmorePacific Corp.)
- Published : 2002.10.01
Abstract
Since capsaicin was found as an excellent vanilloid receptor agonist, considerable efforts toward the development of a novel analgesic have been continued. However, the small therapeutic window between these effects and the excitatory side effects, such as hypothermia, bronchoconstriction, increased GI mobility, and hypertension, precluded the development of capsaicin as a systemic agent. (omitted)
Keywords