Isolation of ACE Inhibiting Peptide from Thermolysin Hydrolysate of Manila clam, Ruditapes philippinarum Proteins

  • Lee, Tae-Gee (Department of Marine Food Industry, Nambo Provincial College of Jeonnam) ;
  • Yeum, Dong-Min (Department of Food Processing & Baking, Yangsan Colleg) ;
  • Kim, Jin-Soo (Division of Marine Bioscience/Institute of Marine Industry, Gyeongsang National University) ;
  • Kim, In-Soo (Division of Marine Bioscience/Institute of Marine Industry, Gyeongsang National University) ;
  • Kim, Seon-Bong (Faculty of Food and Biotechnology, Pukyong National University)
  • Published : 2002.10.01

Abstract

The angiotensin converting enzyme (ACE) generates the powerful vasoconstrictor angiotensin II by removing the C-terminal dipeptide from the precursor decapeptide angiotensin I (1). The enzyme also inactivates the vasodilator bradykinin (2). There have been many studies on ACE inhibitory substances as functional in food, and ACE inhibitory peptides were isolated (3-5). (omitted)

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