Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)
- 2002.06a
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- Pages.92-92
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- 2002
Tumorigenesis of Transgenic Mice Induced by Mouse Vasopressin-SV40 T Hybrid Oncogene
- Lee, Eun-Ju (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical College) ;
- Kim, Myoung-Ok (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical Colleg) ;
- Kim, Sung-Hyun (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical Colleg) ;
- Park, Jun-Hong (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical Colleg) ;
- Park, Jung-Ok (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical Colleg) ;
- Cho, Kyong-In (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical Colleg) ;
- Park, Hum-Dai (Department of Biotechnology, College of Engineering, Taegu University) ;
- Ryoo, Zae-Young (Laboratory of Animal Science, Kangnam St.Mary′s Hospital, Catholic Medical College)
- Published : 2002.06.01
Abstract
The neuropeptide vasopressin (VP) is a nine- amino acid hormone synthesized as preprohormone in the cell bodies of hypothalamic magnocellular neurons. The tumor in magnocellular neurons of the hypothalamus is associated with disfunctions of the cell bodies, leading to the diabetes insipidus. In order to produce the disease models with a defect in VP synthesis and its secretion, we have produced the transgenic mice regulated by VP constructs containing 3.8 kbp of the 5'flanking region and all the exons and introns in the mouse VP gene, which was fused at the end of exon 3 to a SV40 Tag. The two VP-transgene constructs differed by the lengths of their VP gene 3' flanking regions (2.1 versus 3.6 kbp). (omitted)