Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.11b
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- Pages.160-160
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- 2002
THE TOXICITY OF ACEPOROL 460 AS A NOVEL HIGH LOADING CAPACITY SOLUBILIZER OF PACLITAXEL
- Kim, Yeo-Woon (College of Pharmacy, Ewha Womans University) ;
- Kim, Ja-Young (College of Pharmacy, Ewha Womans University) ;
- Cho, Min-Jung (College of Pharmacy, Ewha Womans University) ;
- Song, Hye-Weon (College of Pharmacy, Ewha Womans University) ;
- Lee, Min-Jae (College of Pharmacy, Ewha Womans University) ;
- Kim, Jong-Jae (College of Pharmacy, Ewha Womans University) ;
- Lee, Mi-Suk (College of Pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- Published : 2002.11.01
Abstract
Previously, we reported a novel polymeric micellar solubilizer, Aceporol 330, that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study, we have developed a new micellar solubilizer, Aceporol 460, that has 3-4 times higher lading capacity for paclitaxel than Aceporol 330.(omitted)