한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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- Pages.107-108
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- 2001
Genetic Polymorphism of CYP2A6 and its Effects on the Tobacco-related Lung Cancer Risk
- Kamataki, Tetsuya (Graduate School of Pharmaceutical Sciences, Hokkaido University)
- 발행 : 2001.05.01
초록
During the course of pharmacokinetic studies of SM 12502 which was underdevelopment as an anti-PAF agent, we found that there were three subjects who showed a slow metabolic phenotypeinits pharmacokinetics. Since this compound was oxidized specifically by CYP2A6, we analyzed the genes for CYP2A6 of the three subjects. The results indicated that the three subjects possessed the whole CYP2A6 gene deletion genotype.(omitted)
키워드