Feedback Regulation of ATP-induced $Ca^{2+}$ Signaling in HL-60 Cells

  • Lee, Hyosang (Department of Life Science, Pohang University of Science and Technology) ;
  • Suh, Byung-Chang (Department of Life Science, Pohang University of Science and Technolog) ;
  • Kim, Kyong-Tai (Department of Life Science, Pohang University of Science and Technology)
  • Published : 1997.07.01

Abstract

In HL-60 cells, extracellular A TP increases intracellular $Ca^{2+}$ ([Ca$^{2+}$]$_{i}$) in a concentration-dependent manner with the maximal response occurring around 10 $\mu$M. However, above the maximal responsive concentration ATP elicits different patterns of $Ca^{2+}$ signaling.(omitted)d)

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