Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Block of HERG Channels Expressed in Xenopus oocytes by External$Ca^{2+}$

  • Kim, Injune (Dept. of Life Science, Pohang University of Science and Technology) ;
  • Ho, Won-Kyung (Dept. of Physiology, Seoul National University, College of Medicin) ;
  • Chung, Yu-Jeong (Dept. of Physiology, Seoul National University, College of Medicin) ;
  • Earm, Yung-E (Dept. of Physiology, Seoul National University, College of Medicin) ;
  • Lee, Chin-Ok (Dept. of Life Science, Pohang University of Science and Technology)
  • Published : 1997.07.01
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Abstract

Rapidly activating delayed K current (IKr) in cardiac muscles plays an important in repolarization. Expression of HERG cloned by the study on inherited LQT revealed that it encodes a potassium channel with biophysical properties similar to those of IKr in cardiac myocytes： outward currents activating on depolarization with large tail currents on repolarization, implying the inward rectifying property.(omitted)

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