Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 1997.07a
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- Pages.24-24
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- 1997
Increase of Large Conductance $Ca^{2+}$ -Activated $K^+$ (Maxi-K) Channel Activities by Nitric Oxide (NO) is due to Destabilizing the Long Closure State
- Shin, Jung-Hoon (Department of Physiology and Biophysics, Inha Univ. College of Medicine) ;
- Sungkwon Chung (Department of Physiology, Chung-Ang Univ. College of Medicin) ;
- Park, Eun-Joo (Department of Physiology and Biophysics, Inha Univ. College of Medicin) ;
- Uhm, Dae-Yong (Department of Physiology, Sung Kyun Kwan Univ. College of Medicin) ;
- Suh, Chang-Kook (Department of Physiology and Biophysics, Inha Univ. College of Medicine)
- Published : 1997.07.01
Abstract
We have investigated whether NO affects the activities of the rat brain Maxi- K channels reconstituted into the lipid bilayer. In order to introduce NO, we utilized an antibiotic, streptozotocin (STZ), which releases NO upon illumination. While adding STZ itself did not affect the channel activity, turning on the light in the presence of STZ induced an increase in the open probability (Po) of the channel.(omitted)
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