Effects of Various Detergents on the Tolaasin-induced Hemolysis and the Tolaasin-induced Channel

  • Park, Kyoung-Sun (Department of Agricultural Chemistry, Chungbuk National University) ;
  • Kim, Young-Kee (Department of Agricultural Chemistry, Chungbuk National University)
  • Published : 1997.07.01

Abstract

Tolaasin, a 1.9 kDa peptide forming membrane pores, is produced by Pseudomonas tolaasii and causes a brown blotch disease on cultivated oyster mushroom. During the purification of peptide by a gel permeation chromatography, we have found that fractions of molecular weight ranges between ∼2 to 40 kDa have hemolytic activities and the fractions of higher M.W. showed faster hemolysis.(omitted)

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