Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-oxidant and Anti-aging Activities of Sericinjam Gland Hydrolysate Extract in Human Dermal Fibroblasts

사람 섬유아세포에서 세리신잠 실샘가수분해물(Sericinjam Gland Hydrolysate)의 항산화 및 항노화 효과

  • Cheon, Yuri (Department of Applied Bioscience, CHA university) ;
  • Hwang, Jung Wook (Department of Applied Bioscience, CHA university) ;
  • Lee, Heui Sam (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA) ;
  • Yun, Seiyoung (Department of Pharmaceutical Cosmetics, Gwangju Women's University) ;
  • Choi, Yong-Soo (Department of Applied Bioscience, CHA university) ;
  • Kang, Sangjin (Department of Applied Bioscience, CHA university)
  • 천유리 (차의과학대학교 바이오산업응용학과) ;
  • 황정욱 (차의과학대학교 바이오산업응용학과) ;
  • 이희삼 (농촌진흥청 국립농업과학원 잠사양봉소재과) ;
  • 윤세영 (광주여자대학교 제약향장학과) ;
  • 최용수 (차의과학대학교 바이오산업응용학과) ;
  • 강상진 (차의과학대학교 바이오산업응용학과)
  • Received : 2012.09.07
  • Accepted : 2012.10.30
  • Published : 2013.03.31
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Abstract

We studied the anti-oxidant and anti-aging activities of Sericinjam Gland Hydrolysate (SJGH) in the human dermal fibroblasts. SJGH effectively defended cell death and ROS generation under high H2O2 in human dermal fibroblasts. Moreover SJGH reduced the expression of SA-${\beta}$-Gal and MMP-1 under low concentration of $H_2O_2$ whereas biosynthesis of procollagen-I was increased. This results demonstrate the anti-oxidant and anti-aging activities of SJGH. SJGH could be a good candidate for anti-aging cosmetics ingredient.

본 논문에서는 세리신잠 실샘 가수분해물(Sericinjam Gland Hydrolysate: SJGH)을 이용하여 진피 섬유아세포에서 항산화 및 항노화 연구를 진행하였다. SJGH는 사람 섬유아세포에서 고농도의 과산화수소에 의한 세포사멸과 세포 내 산화 증가를 효과적으로 방어하였다. 또한 SJGH는 저농도의 과산화수소에 의한 섬유아세포의 SA-${\beta}$-Gal 발현과 MMP-1의 발현 증가를 억제하였고, 반대로 프로콜라겐 I의 생합성은 증가시켰다. 이러한 결과를 통해 SJGH의 항산화 및 항노화 효과가 우수함을 확인하였으며, SJGH가 항노화 화장품의 우수한 소재가 될 수 있음을 보여준다.

Keywords

References

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