Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Pharmacological action and Toxicity of Angelica sinensis

당귀(Angelica sinensis)의 임상활용에 대한 효능 및 부작용연구

  • Park, Yeong-Chul (GLP Center, Catholic University of Dae-Gu) ;
  • Lee, Ji-Sun (GLP Center, Catholic University of Dae-Gu) ;
  • Kim, Min-Hee (GLP Center, Catholic University of Dae-Gu) ;
  • Kim, Dong-Yoon (GLP Center, Catholic University of Dae-Gu) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sang-Ji University)
  • 박영철 (대구가톨릭대학교 GLP센터) ;
  • 이지선 (대구가톨릭대학교 GLP센터) ;
  • 김민희 (대구가톨릭대학교 GLP센터) ;
  • 김동윤 (대구가톨릭대학교 GLP센터) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2011.10.12
  • Accepted : 2011.11.14
  • Published : 2011.12.30
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Abstract

Objectives : Angelica sinensis has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Angelica sinensis has been identified newly using animal models. In addition, it was reported that reactive intermediates, potentially causing toxic effects, was isolated from components in Angelica sinensis. In this article, it was purposed for explanation and introduction of new studies for Angelica sinensis. in terms of Pharmacological action and Toxicity. Methods : New studies for Angelica sinensis were reviewed and summarized in terms of pharmacological action and toxicity. Results and Conclusions : Angelica sinensis and its components including phthalide, phthalide dimers, polysaccharides, polyacetylenes, ligustilide와 butylidenephthalide as well as organic acid showed a variety of pharmacological actions on uterine, cardiovascular system and immune system. In addition, it was identified that three components of such as ligustilide, caffeic acid and safrole was biotransformed to reactive intermediates causing possibly toxicity.

Keywords

References

  1. Zhu DP. Dong quai. Am J Chin Med. 1987;15:117-25. https://doi.org/10.1142/S0192415X87000151
  2. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL:CRC Press. 1999.
  3. Lunzhao Yi, Yizeng Liang, HaiWu, Dalin Yuan. The analysis of Radix Angelicae Sinensis(Danggui). Journal of Chromatography A, 2009;1216:1991-2001. https://doi.org/10.1016/j.chroma.2008.07.033
  4. Hou YZ, Zhao GR, Yang J, et al. Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide. Life Sci. 2004;75:1775-86. https://doi.org/10.1016/j.lfs.2004.05.005
  5. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebocontrolled trial. Fertil Steril. 1997;68:981-6. https://doi.org/10.1016/S0015-0282(97)00397-X
  6. Dietz, BM, D. Liu, GK Hagos, P Yao, A Schinkovitz, SM Pro, S Deng, NR Farnsworth, GF Pauli, RB vanBreemen, JL Bolton, Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H:quinone oxidoreductase 1 by alkylating Keap1. Chem Res Toxicol. 2008;21(10):1939-48. https://doi.org/10.1021/tx8001274
  7. Dietz, BM, Judy L. Bolton. Biological reactiveinter mediates(BRIs) formed from botanical dietary supplements. Chemico-Biological Interactions. In Press, Available online 21 October 2010.
  8. Sun, Y, J. Tang, X. Gu, D. Li, Water-soluble polysaccharides from Angelica sinensis(Oliv.) Diels: Preparation, characterization and bioactivity. Int J Biol Macromol. 2005;36:283-90. https://doi.org/10.1016/j.ijbiomac.2005.07.005
  9. Beck JJ, SC, Chou. The Structural diversity of phthalides from the Apiaceae. J Nat Prod. 2007;70:891-900. https://doi.org/10.1021/np0605586
  10. Q. Wang, Y. Fang, Analysis of sugars in traditional Chinese drugs. J Chromatogr B. 2004;812:309-24. https://doi.org/10.1016/S1570-0232(04)00763-9
  11. Du, JR, Bai, B, Kuang, X, Yu, Y, Wang, CY, Ke, Y, Xu, YJ, Tzang, HC, Qian, ZM, Ligustilide inhibits spontaneous and agonistsor K+ depolarization-induced contraction of rat uterus. Journal of Ethnopharmacology. 2006;108:54-8. https://doi.org/10.1016/j.jep.2006.04.011
  12. Du, J, Yan Yua, Ya Ke, Chenyuen Wang, Li Zhua, Zhong Ming Qian. Ligustilide attenuates pain behavior induced by acetic acid or formalin. Journal of Ethnopharmacology. 2007;112:211-4. https://doi.org/10.1016/j.jep.2007.02.007
  13. Tieraona Low. Dog Menopause: a review of botanical dietary supplements The American Journal of Medicine. 2005;118(12B):8S-08S. https://doi.org/10.1016/j.amjmed.2005.09.008
  14. Hirata JD, Swiersz LM, Zell B, et al. Does Dong quai have estrogenic effects in postmenopausal women? A double-blind, placebocontrolled trial. Fertil Steril. 1997;68:981-6. https://doi.org/10.1016/S0015-0282(97)00397-X
  15. DerMarderosian A, Beutler J, eds. The Review of Natural Products. St. Louis, MO; Facts and Comparisons Publishing Group. 2004.
  16. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL:CRC Press. 1999.
  17. Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. London, UK:Churchill Livingstone. 2000:350-3.
  18. Robert R. Bradley, Paula J. Cunniff, Brian J.G. Pereira, Bertrand L. Jaber. Hematopoietic effect of Radix angelicae sinensis in a hemodialysis patient, American Journal of Kidney Diseases. 1999;34(2):349-54. https://doi.org/10.1016/S0272-6386(99)70367-7
  19. Skidmore-Roth L. Mosby' Handbook of Herbs & Natural Supplements. St. Louis, MO: Mosby, Inc. 2001.
  20. Wilasrusmee C, Siddiqui J, Bruch D, et al. In vitro immunomodulatory effects of herbal products. Am Surg. 2002;68:860-4.
  21. Wilasrusmee C, Kittur S, Siddiqui J, et al. In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes. J Altern Complement Med. 2002;8:467-75. https://doi.org/10.1089/107555302760253667
  22. Antiviral Chinese medicinal herbs against respiratory syncytial virus Shuang-Cheng Ma, Jiang Du, Paul Pui-Hay But, Xue-Long Deng, Yong-Wen Zhang, Vincent Eng-Choon Ooi, Hong-Xi Xu, Spencer Hon-Sun Lee, Song Fong Lee b Journal of Ethnopharmacology. 2002;79:205-11. https://doi.org/10.1016/S0378-8741(01)00389-0
  23. Xingbin Yang, Yan Zhao, Guoli Li, Zhezhi Wang, You Lv Chemical composition and immuno-stimulating properties of polysaccharide biological response modifier isolated from Radix Angelica sinensis. Food Chemistry. 2008;106:269-76. https://doi.org/10.1016/j.foodchem.2007.05.085
  24. Zhaohui Zhao, Mohammed H. Moghadasian. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. Food Chemistry. 2008;109:691-702. https://doi.org/10.1016/j.foodchem.2008.02.039
  25. Rosanna Y.Y. Lama, Zhi-Xiu Lina, Elena Sviderskayab, Christopher H.K. Chengc, O. Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment. Journal of Ethnopharmacology. 2010;132:274-9. https://doi.org/10.1016/j.jep.2010.08.027
  26. Cheng Chang Ho, Alaganandam Kumaran, Lucy Sun Hwang. Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis. Food Chemistry. 2009;114:246-52. https://doi.org/10.1016/j.foodchem.2008.09.046
  27. Xi Kuang, Jun-Rong Du, Ya-Shu Chen, Jing Wang, Yan-Nan Wang Pharmacology, Protective effect of Z-ligustilide against amyloid $\beta$-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains. Biochemistry and Behavior. 2009;92:635-41. https://doi.org/10.1016/j.pbb.2009.03.007
  28. Xi Kuang, Jun-Rong Du, Yan-Xin Liu, Guang-Yi Zhang, Hai-Yan Peng Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. 2007;88(3):213-21.
  29. Kuang Xi, Yao Y, Du JR, Liu YX, Wang CY, Qian ZM. Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Brian Res. 2006;1102:145-53. https://doi.org/10.1016/j.brainres.2006.04.110
  30. Ru Yan, Nga Ling Ko, Song Lin Li, Yun Kau Tam, and Ge Lin Pharmacokinetics and Metabolism of Ligustilide, a Major Bioactive Component in Rhizoma Chuanxiong, in the Rat. Drug Metabolism and Disponsition. 2008;36(2):400-8. https://doi.org/10.1124/dmd.107.017707
  31. AM Jeffrey, GM Williams. Risk assessment of DNA-reactive carcinogens in food Toxicology and Applied Pharmacology. 2005;207:S628-S35. https://doi.org/10.1016/j.taap.2005.03.024
  32. Yoshio Nakagawa, Toshinari Suzuki, Kazuo Nakajima, Hidemi Ishii, Akio Ogata Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes. Chemico-Biological Interactions. 2009;180:89-97. https://doi.org/10.1016/j.cbi.2009.02.003
  33. Chiu-Lan Chen, Chin-Wen Chi, Kuo-Wei Chang, Tsung Yun Liu. Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history. Carcinogenesis. 1999;20(12):2331-4. https://doi.org/10.1093/carcin/20.12.2331
  34. KH Janbaz, SA Saeed, AH Gilani, Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine. 2004;11:424-30. https://doi.org/10.1016/j.phymed.2003.05.002
  35. 박영철, 독성학의 분자-생화학적 원리. 한국학술정보(주). 2010.
  36. Website: Dr. Pan's Clinic of TCM: Dang-gui.
  37. Noe, Jody E. Angelica Sinensis: a Monograph. Journal of Naturopathic Medicine. HerbClip. 1998.