• Journal of Ginseng Research
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• v.41 no.4
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• pp.540-547
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• 2017

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at $37^{\circ}C$ for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LC-MS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LC-MS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.159-166
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• 2004

The following study was undertaken in order to seek the acupuncture operation method of $\ll$Sang Han Lun(傷寒論)$\gg$ Liu-Jing-Bian-Zheng(六經辯證). Based on the documents quoted in $\ll$Sang Hang Za Bing Lun Xu Wen(傷寒雜病論 序文)$\gg$ of "Zhang, Zhong-Jing(張仲景)", the relativity of the theory of Jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused Tai- Yin-Bing(太陰病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of $\ll$Sang Han Lun$\gg$. As a result of the foregoing study, the author has written the following acupuncture operation on the basis of a summarized Tai-Yin-Bing for $\ll$Sang Han Lun$\gg$ Liu-Jing-Bian-Zheng. Results : $\ll$Sang Han Lun$\gg$ Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) of $\ll$Su Wen Re Lun(素問 熱論)$\gg$. In addition, the summary of Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫려) and Zabing(雜病). 2. Most commentators of $\ll$Sang Han Lun$\gg$ in the Song, Ming and Ching Dynasties of $\ll$Sang Han Lun$\gg$ interpreted the Tai-Yang-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the spleen meridian. 3. From the Liu-Jing-Bing of $\ll$Sang Han Lun$\gg$, the region of acupuncture treatment of Tai-Yang-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the spleen meridian.

• Journal of Acupuncture Research
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• v.24 no.2
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• pp.203-210
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• 2007

Objectives: The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-jing-Bian-Zheng(六經辨證) Methods : Based on the documents quoted in ${\ll}$Sang Han Lun ${\cdot}$ Xu Wen(傷寒雜病論 ${\cdot}$ 序文)${\gg}$ of "Zhang, Zhong-jing(張仲景)", the relativity of the theory of jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-jing-Bing(六經病), the origin and implication that caused Yang-Ming-Bing(陽明病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results: 1. ${\ll}$Sang Han Lun${\gg}$ Liu-jing-Bian-Zheng has succeeded and was developed based on Liu-jing-Fen-Zheng(六經分證) of ${\ll}$Su Wen ${\cdot}$ Re Lun(素問 ${\cdot}$ 熱論)${\gg}$. In addition, the summary of Liu-jing-Bing became the general principle of Fen-jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili and Zabing(雜病). 2. Most commentators of ${\ll}$Sang Han Lun${\gg}$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$ interpreted the Yang-Min-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the Stomach meridian and Large Intestine meridian. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treatment of Yang-Min-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the Stomach of meridian ${\cdot}$ Large Intestine of meridian.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.725-743
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• 2000

This study was intended to investigate the contents associated with the neuropsychosis in the medical books published in the times of Chinese dynasty of Jin and Yuan. As a result, the following findings were drawn. 1. As for palpitation from fright and severe palpitation, the medical schools in the times of Chinese Jin and Yuan dynasties viewed their causes as heart-fire, shuiqichengxin, blood vacuity, phlegm and so on and presented a prescription for each cause for them. 2. As for psychosis, medical books published in the times of Chinese Jin and Yuan dynasties accurately divided and discussed epilepsy and viewed their causes largely as Yangming heat, phlegm of chest and heart-fire. And a number of medical schools made use of such therapeutics as sweating, vomiting and diarrhea therapies. 3. As for headache, medical books published in the times of Chinese Jin and Yuan dynasties presented their causes as fire and heat, phlegm heat, phlegm and so on and classified the aspect of headache in detail. As for vacuity rexation and dysphoria, medical books at that time saw their causes as fire and heat, heart-fire, blood vacuity and so forth and presented a prescription for them accordingly. 4. Liu Wan Su was the Hanliang school. He viewed the etiological cause for psychopathy as fire and heat and prescribed largely the medication of cold nature for it. 5. Zhang Cong Zheng belonged to the Gongxia School. He viewed the etiological cause for psychopathy as fire, phlegm and so forth and made use of sweating, vomiting and diarrhea therapies. Especially, he used the 'Jingzhepingzhe' therapy as a method to treat the symptom of fright. 6. Li Gao did not any specific mention of psychopathy and divided headache due to internal injury and headache due to external contraction. 7. Zhu Zhen Heng viewed most of the etiological causes for psychopathy as phlegm, fire and deficiency of blood and attached importance to such its therapeutics as resolving phlegm, cleaning away fire and nourishing Yin. 8. Wang Hao Gu did not present the specifically common etiological cause and prescription for psychopathy but described the cause and prescription for headache, dysphoria, maniac speech, palpitation and so forth. Luo Tian Yi presented the process of psychosis due to abnormal therapy for cold demage and prescription of it. 9. Wang Lu made a detailed explanation about the therapeutics of five types of stagnated syndrome and said that stagnated syndrome became the major cause for them in the occurrence of such psychopathy. Wei Yi Lin presented the prescription and medication for comparatively diverse mental diseases such zhong-qi, severe palpitation, palpitation for fright, impaired memory, vacuity rexation, headache, psychosis.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.9 no.3
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• pp.129-138
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• 2014

After global economic crisis, China has become one of the two pillars in the global economies and the country contributing to the Korean economy. Nevertheless, the research on Chinese financial market, particularly capital market, is rare to date. This study examined the growth enterprise market that emergedat the Shenzhen stock exchange and made comparative analysis on before and after listing for the Chinese small and medium sized firms and venture firms. The listing requirements at the Chinese growth enterprise market for the technologically innovative venture firms and fast-growing small and medium sized firms with financing purpose were more alleviated than the main board of Shenzhen stock exchange. Moreover, the listing procedures are simplified as well. Accordingly, many Chinese enterprises tend to list and the competition for listing is also intense. In particular, with the 36 initially listed firms at growth enterprise market as the research target, the investigation for the business performance before and after listing reveals that the three indexes including return on common equity, debt ratio and operating profit growth rate dropped dramatically for most all the firms. That is, the profitability and growth for the venture firms and small and medium sized firms listed on the Chinese growth enterprise market decreased rapidly after going public, only the stability improved due to the great financing. Taking a step forward, this phenomenon may result from the exaggerated reporting for the business performance before listing with the purpose of going public by the venture firms and small and medium sized firms. Thus, Chinese Securities Regulatory Commission should strengthen the accounting evaluation standard and regulation for the listing firms before going public. In addition, strict sanctions should be imposed on the firms with fraudulent accounting to establish healthy capital market.

• Nuclear Engineering and Technology
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• v.49 no.1
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• pp.54-70
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• 2017

The accumulator is a passive safety injection device for emergency core cooling systems. As an important safety feature for providing a high-speed injection flow to the core by compressed nitrogen gas pressure during a loss-of-coolant accident (LOCA), the accumulator injects its precharged nitrogen into the system after its coolant has been emptied. Attention has been drawn to the possible negative effects caused by such a nitrogen injection in passive safety nuclear power plants. Although some experimental work on the nitrogen injection has been done, there have been no comparative tests in which the effects on the system responses and the core safety have been clearly assessed. In this study, a new thermal hydraulic integral test facility-the advanced core-cooling mechanism experiment (ACME)-was designed and constructed to support the CAP1400 safety review. The ACME test facility was used to study the nitrogen injection effects on the system responses to the small break loss-of-coolant accident LOCA (SBLOCA) transient. Two comparison test groups-a 2-inch cold leg break and a double-ended direct-vessel-injection (DEDVI) line break-were conducted. Each group consists of a nitrogen injection test and a nitrogen isolation comparison test with the same break conditions. To assess the nitrogen injection effects, the experimental data that are representative of the system responses and the core safety were compared and analyzed. The results of the comparison show that the effects of nitrogen injection on system responses and core safety are significantly different between the 2-inch and DEDVI breaks. The mechanisms of the different effects on the transient were also investigated. The amount of nitrogen injected, along with its heat absorption, was likewise evaluated in order to assess its effect on the system depressurization process. The results of the comparison and analyses in this study are important for recognizing and understanding the potential negative effects on the passive core cooling performance caused by nitrogen injection during the SBLOCA transient.

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.15-28
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• 1998

One's constitution is formed congenitally and is also acquired, and is relatively stable in its individually manifested function, structure and temperament. It has characteristics of universality, complexity, generality and continuity. It is also manifested in physiological responses and expresses pathologic tendencies including susceptibility. Attempts at understanding constitution has had a long history throughout the world. In Oriental Medicine, the constitution had been acknowledged from the "Huangdi Neijing", which has been a bible in Oriental Medicine for about two thousand years. In many aspects, the "Huangdi Neijing" provides the basis for both basic and practical fields. In order to derive the ideal structure from the "Huangdi Neijing" to Lee Je-ma's(Lee Jayma's) Sasang Constitutional ideas, which can strengthen the understanding of ideal core of Oriental Medicine's constitutional characteristics, the author launched his analysis of the constitutional understandings in the "Huangdi Neijing" as a first step and came to the following: 1. The constitutional understanding in the "Huangdi Neijing" was done both via the physiological responses to heat, pain and acupuncture treatment and the pathologic tendencies via body structure, strength, body heat, courage and obesity. 2. It was recognized that the constitution was formed congenitally and also acquired factors like living conditions including food customs, residents and geographical conditions were explained in detailed. 3. The constitutional typology was suggested both by the general and systematic criterion according to the Yin-yang and the Five phase theories and by single criterion such as obesity, courage and the response to acupuncture treatment. 4. As diagnosis is related to the constitution, courage was adopted for the disease caused by emotions, obesity was for its manifestations of qi and blood, the quantities of qi-blood and Yin-yang in the typology by the Yin-yang and Five phase theories were suggested. 5. In the case of obesity, Yin-yang and Five phase theory, treatment according to the constitutional ideas was mentioned, and their goals were concluded as "being the balancing between Yin and Yang" which means the Yin-yang theory is more practical than the Five phase theory in Oriental Constitutional Medical field. According to the above understandings, the author would like to suggest that the constitutional ideas in the "Huangdi Neijing" based on the Yin-yang theory blossomed via the practical spirit of Zhang Zhong-jing's "Shanghanlun" and at last from Lee Je-ma's(Lee Jayma's) Sasang Constitutional Medicine which realized "the balancing between Yin and yang" through the practical applications of herbal treatments.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.28 no.4
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• pp.431-439
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• 2010

Cross-interferometic synthetic aperture radar (CInSAR) technique from ERS-2 and Envisat images is capable of generating submeter-accuracy digital elevation model (DEM). However, it is very difficult to produce high-quality CInSAR-derived DEM due to the difference in the azimuth and range pixel size between ERS-2 and Envisat images as well as the small height ambiguity of CInSAR interferogram. In this study, we have proposed an efficient method to overcome the problems, produced a high-quality DEM over northern Alaska, and compared the CInSAR-derived DEM with the national elevation dataset (NED) DEM from U.S. Geological Survey. In the proposed method, azimuth common band filtering is applied in the radar raw data processing to mitigate the mis-registation due to the difference in the azimuth and range pixel size, and differential SAR interferogram (DInSAR) is used for reducing the unwrapping error occurred by the high fringe rate of CInSAR interferogram. Using the CInSAR DEM, we have identified and corrected man-made artifacts in the NED DEM. The wave number analysis further confirms that the CInSAR DEM has valid Signal in the high frequency of more than 0.08 radians/m (about 40m) while the NED DEM does not. Our results indicate that the CInSAR DEM is superior to the NED DEM in terms of both height precision and ground resolution.

• Journal of the Korean Institute of Landscape Architecture
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• v.45 no.6
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• pp.90-97
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• 2017

Construction of urban emergency shelters based on disaster-prevention green space is an important part of an urban disaster response plan. The accessibility of disaster-prevention green space is directly related to the disaster prevention service effect of green space. Taking the Jung-gu and Nam-gu districts of Ulsan city as research targets, the accessibility of three green spaces was analyzed by a network analysis method based on information regarding the distribution of population and green space and the urban road network. Two indicators for evaluating the service effect of green spaces were service population rate and service area rate. The results showed that the accessibility of the emergency refuge parks (5min) and central refuge parks was relatively good but the service area rate and service population rate of the emergency refuge parks (3min) and temporary refuge parks was less than 60%. In view of the overall situation, the service effect of disaster-prevention green space is at this point only general in Ulsan and there is great room for improvement.

• Journal of the Korean Institute of Landscape Architecture
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• v.45 no.6
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• pp.149-159
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• 2017

There are many studies on the health and protection of Old-growth and Giant Trees, concentrating on empirical judgment and basic protection measures. The problem this study addresses is the relative importance and priority of the health evaluation indicators of Old-growth and Giant Trees. Firstly, this study exports the evaluation indicators of Old-growth and Giant Trees. The evaluation system for the degree of danger of Old-growth and Giant Trees are composed of two layers: 5 fields and 46 indicators. Secondly, using the AHP and PCA method can determine the weight of each field and each index factor. The process of AHP establishes the relative importance judgment matrix of each field and fully proves that the main cause of danger is individual aging. The PCA method suggested that trunk rot status, light conditions, tree surgeries, bacterial diseases, and soil moisture level are the most important factors in each field. These aspects should be given priority in the management and protection of Old-growth and Giant Trees. Weight values obtained in this study seemed to be useful in the evaluation of Old-growth and Giant Trees.