• PNF and Movement
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• v.1 no.1
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• pp.33-41
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• 2003

Objectives : The purpose of this study was to describe and compare the temporo-spatial gait characteristics of healthy young people with those of healthy elderly people. Methods: The data were collected by 40 volunteers. 20 subjects were between 20 and 31 years of age, and 20 subjects were between 65 and 84 years of age. Temporal and spatial parameters of gait were analysed for using the computerized GAITRite system. Results : The system integrates specific components of locomotion to provide a single, numerical representation of gait, the Functional Ambulation Performance score. Differences in gait characteristics between the two groups were examined using a correlated t-test(p<.05). Significant differences were observed between the groups for step length, step/extremity ratio and velocity. Young people demonstrated a significantly larger velocity, step length and step/extremity ratio than the elderly people. Conclusions: These results indicate that the GAITRite system can be useful in detecting footfall patterns and selected time and distance measurements of young and older persons. Additionaly, differences in walking velocity, step length and step/extremity ratio between old and young people may have influenced the gait characteristics measured.

• Journal of the Korea Safety Management & Science
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• v.13 no.3
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• pp.29-35
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• 2011

Safety and health related information for the proper use and handling of pesticides is usually printed on the surface of the pesticide products (bottle type or bag type) in the form of texts. But, the guidelines or standards for the appropriate presentation of the texts for the pesticide products are most vague or not practical. Thus, this study aimed to provide the preliminary guidelines for the text sizes based on the legibility experiments. Total twenty subjects from two age groups (young: n=10, old: n=10, five males and five females in each group) participated in the experiment. First, subjects read the text cards presented in the distance of 50cm from the eyes of the subjects. Eight different text card sets were prepared for different font type(thick gothic-type and fine gothic-type), thickness of font(plain and bold), and number of syllables (2 and 3 syllables). When subjects read the cards, the correctness of reading (correct or wrong) was recorded and the degree of discomfort (from 1: no discomfort at all to 4: can't read at all) was also evaluated for all the text sizes. Results showed that the character size should be 4 pt or larger for the young subjects to read at least one word correctly in all the text conditions. For the old subjects to read at least one word correctly, the character size should be five pt or larder. The average of the minimum character sizes for 100% correct answer is 6.1 pt for young subjects and 10.5 pt for old subjects, respectively.

• Clinics in Shoulder and Elbow
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• v.27 no.3
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• pp.327-337
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• 2024

Background: Anterior combined latissimus dorsi and teres major (aLDTM) tendon transfer has shown promise as a treatment for anterior superior irreparable rotator cuff tears (ASIRCTs). Our study aimed to compare aLDTM clinical outcomes for ASIRCTs between young and elderly patients. Methods: This retrospective study reviewed data from patients who underwent aLDTM tendon transfer for ASIRCTs with minimum 2-year follow-up. Clinical evaluations included visual analog scale (VAS), American Shoulder and Elbow Surgeons (ASES) score, Single Assessment Numeric Evaluation (SANE), active range of motion (aROM), strength, and complications. Radiologic assessments included acromiohumeral distance, Hamada classification, and integrity of transferred tendon. Patients were divided into group total (all ages), group old (≥70 years), and group young (≤60 years). Results: A total of 123 patients were enrolled with 39 in group young (mean age, 56.6±4.9 years) and 27 in group old (mean age, 73.6±2.3 years). Postoperatively, both groups showed significant improvements in VAS, ASES, and SANE scores and improved aROM for forward elevation, abduction, and internal rotation. No significant differences in clinical coutcomes were noted between the groups. Furthermore, similar rates of complications, including retears and postoperative infections, were observed across all three groups. Conclusions: Our study highlights the effectiveness of aLDTM transfer for ASIRCTs with minimal glenohumeral arthritis, demonstrating similar outcomes in both group young and group old patients. Moreover, patients in these distinct age groups showed comparable clinical results when compared to group total.

• The Korean Journal of Ecology
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• v.11 no.2
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• pp.83-95
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• 1988

Phytomass, annual net production, respiration, annual gros production and litter fall were estimated in young Korean pine (Pinus koraiensis) plantations reforested 1,2,3,6,9 and 11 years ago, respectivly. The estimated phytomasses in terms of allometry were 0.07, 0.44, 0.58, 13.37, 32.26 and 48.42ton/ha/yr for annual net production and those of understory with harvest method were 3.70, 4.52, 5.28, 6.72, 7.56 and 5.72ton/ha for standing phytomass and 5.01, 4.71, 5.52m 6.15, 4.51 and 2.08 ton/ha/yr for annual net production at 1,2,3,6,9 and 11 year old plantation, respectively. Although the standing phytomass of understory increased gradually until 9 years thereafter decreased, that of white pine increased suddenly from 6 years after reforestation. The ratios of the annyal net production of understory to that of white pine were 71.57, 1.48 and 0.23 at 1,6 and 11 year old plantations, respectively. The net production in calorie value for whole vegetation of the plantations, respectively. The net production in calorie value for whole vegetation of the plantations increased until 9 years thereafter decreased; i.e. 224, 221, 280, 466, 527 and 494X105 kcal/ha/yr at 1,2,3,6,9 and 11 year old plantation, respectivey. The ratio of annual net production to annual gross production of the undersoty was lower than that of the pine at the same plantation age. Efficiency of solat energy untilization for net production by the pine was lower than that by understory y\until six ear old plantation but that was vice versa over 9 year old plantation. That for gross producrion by the pine was lower than that by the unsersotry at all plantations.

• BMB Reports
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• v.48 no.11
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• pp.595-596
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• 2015

Skeletal muscle exhibits a loss of muscle mass and function with age. Decreased regenerative potential of muscle stem/progenitor cells is a major underlying cause of sarcopenia. We analyzed microRNAs (miRNA) that are differentially expressed in young and old myoblasts, to identify novel intrinsic factors that play a degenerative role in aged skeletal muscle. miR-431, one of decreasing miRNAs in old myoblasts, improved the myogenic differentiation when overexpressed in old myoblast, but suppressed their myogenic capability in knockdowned young myoblasts. We found that miR-431 directly binds to 3` untranslated regions (UTR) of Smad4 mRNA, and decreases its expression. Given that SMAD4 is one of the downstream effectors of TGF-β, a well-known degenerative signaling pathway in myogenesis, the decreased miR-431 in old myoblast causes SMAD4 elevation, thus resulting in defective myogenesis. Exogenous expression of miR-431 greatly improved the muscle regeneration in the cardiotoxin-injured hindlimb muscle of old mice by reducing SMAD4 levels. Since the miR-431 seed sequence is conserved in human SMAD4 3'UTR, miR-431 regulates the myogenic capacity of human skeletal myoblasts in the same manner. Our results suggest that age-associated miR-431 is required for the maintenance of the myogenic capability in myoblasts, thus underscoring its potential as a therapeutic target to slow down muscle aging.

• Journal of Veterinary Clinics
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• v.27 no.4
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• pp.402-406
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• 2010

Bovine leukemia virus (BLV) is a delta-retrovirus which causes chronic lymphocytosis in cattle. BLV infections have been divided into two groups such as enzootic bovine leukosis (EBL) and sporadic bovine leukosis (SBL) according to the clinical symptoms in infected cattle. The conventional detection method of BLV was hematological procedure which is determining lymphocytosis in the suspected animals. Recently several sensitive methods were developed to detect antibody to BLV and nucleic acid of the BLV from infected cattle. In this study we have compared the difference of positive rates between agar gel immunodiffusion (AGID) and enzyme linked immunosorbent assay (ELISA) which are using for BLV antibody detection methods. The positive detection rate of ELISA test was 7.4% greater than the positive rate of AGID. The discrepancy of the positive rate between ELISA and AGID were showed in the group of age over one year old to under three year old group. The result from each test agreed very well in the group of over 5 year old cattles. The serological test is very useful method to select the infected cattle for the eradication or control of the disease in the infected herd. But it has a limit by interference of the maternal antibody from the cow of under 6 month old. This study shows that 16.2% of these ages group showed BLV gene positive by polymerase chain reaction (PCR) method. The result suggests that ELISA test need to be used with PCR to clarify misinterpretation of positive animals by antibody response due to the natural infection from maternally derived antibody in calves of under 6 months old.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.10 no.1
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• pp.59-66
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• 2010

Enzyme replacement of therapy (ERT) is one of the most promising therapeutic strategies for the treatment of lysosomal storage disorders. ERT is available in three types of Mucopolysaccharidosis (MPS): for MPS I (Aludrazyme$^{(R)}$), MPS II (Elaprase$^{(R)}$) and MPS VI (Naglazyme$^{(R)}$) patients who are over 5 years old. But recently, early diagnosis can be done by expert clinicians and even in prenatal case. We describe the case of ERT under 5 years old MPS patients. Up to June, 2010 in Samsung Medical Center, there are 6patients who were diagnosed as MPS and started ERT under 5 years old. 3 patients were MPS I, 3 patients were MPS II. 2 patient who was diagnosed as MPS I was female and others were male. Their age at diagnosis were 4 to 37month-old (4, 13, 16, 25, 27, 37 month-old) and they are now 9 to 60 month-old (9, 39, 32, 81, 60 month-old). The youngest patient was started ERT at 4 month-old and others were started at their 13 to 49 month-old (13, 29, 27, 28, 49 month-old). First manifested symptoms of patients were macrocephaly, kyphosis and coarse face appearance. Especially, in 2 of them, one was MPS I and the other was MPS II had elder brother with same disease. And the youngest one was diagnosed by the iduronate-2-sulfatase (IDS) gene analysis from chorionic villi sampling. His mother knew that she was a heterozygous carrier of IDS gene mutation because her younger brother died from MPS II. All of them confirmed as MPS by the enzyme assay in leukocytes and fibroblast skin culture. We started ERT with ${\alpha}$-L-iduronidase(Aldurazyme$^{(R)}$) to MPS I and did recombinant human iduronate-2-sulfatase (Elaprase$^{(R)}$) to MPS II patients as recommended dose as over 5 years old. But for MPS II patient who was 4 month old, we started ERT by recombinant human IDS (Elaprase$^{(R)}$) with reduced dose 0.1 mg/kg and increased dose every 2 weeks by 0.1mg/kg up to 0.5mg/kg IV infusion. During ERT, all patients had no adverse effects and the excretion of GAGs were decreased. We have evaluated other clinical symptoms such as liver/ spleen volume, heart function and neurologic evaluation. We describe a successful ERT to MPS I and MPS II patient under 5 years old without any adverse event. It indicates that ERT in young children are well tolerated and that it has several effects which may confer clinical benefits with long-term therapy.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.35 no.1
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• pp.97-125
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• 2024

The purpose of this study is to increase access to information on old maps and to discuss efficient ways to utilize old maps, such as providing services and information using old maps. To this end, the information search system of domestic institutions that provide old map information was investigated, and methods of searching for old map data and accessing information were searched on the website. In addition, the current status of the collection of old maps in domestic libraries and museums was analyzed by referring to the homepage, book, research book, and publication of each institution. As a result of the analysis, about 2,200 old maps were housed in 76 institutions, including national, public, and university libraries and museums nationwide. Each institution in the collection of old maps was carrying out publication business, such as publication of English manuscripts, exhibitions and books, publication of research document edits such as lists and summaries. However, reading and using of original documents are limited due to the rare nature of old maps and the data characteristics of the only one. In order to effectively utilize old maps, first, it is necessary to improve access to old map information services and expand academic information services. Second, it is proposed to use old maps as data for archival construction that reflects the identity of the region. Third, it is necessary to cultivate professional manpower who selects and provides information based on knowledge of old map data and humanities literacy.

• The Bulletin of The Korean Astronomical Society
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• v.18
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• pp.6.2-7
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• 1993

• Journal of Ginseng Research
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• v.20 no.2
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• pp.206-215
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• 1996