• Korean Journal of Child Studies
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• v.25 no.6
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• pp.1-13
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• 2004

The purposes of this study were to investigate whether there were differences in the young children's abilities to use spatial coordinates and to represent spatial locations by children's age and sex, and to examine the relationship between these two abilities. It also explored whether the young children could use coordinates as the frames of reference for representing spatial locations. Seventy 5- and 6-year-old children from two kindergartens in Seoul and in Bucheon participated in this study. Results indicated that there were statistically significant differences between age groups on the children's ability to use spatial coordinates and to represent spatial locations. However, there were no significant differences between boys and girls on these two abilities. A positive correlation was found between theses two abilities of using spatial coordinates and representing spatial locations. Most of the young children used landmarks as the frames of reference to represent spatial locations while some of the children were partially able to use spatial coordinates. Twenty percent of 6-year-old children were fully able to use spatial coordinates as the frames of reference to represent spatial locations.

• Journal of Korean Neurosurgical Society
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• v.38 no.2
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• pp.107-110
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• 2005

Objective : Lumbar spinal stenosis is increasingly recognized as a common cause of low back pain in elderly patients. Conservative treatment has been initially applied to elderly patients, however, surgical treatment is sometimes indispensable to relieve severe pain. We retrospectively examine the age-related effects on the surgical risk, and results following general anesthesia and operative procedure in geriatric patients for two different age groups of at least 65years old. Methods : Consecutive 51 patients [${\ge}$ 65years], who underwent open surgical procedure for degenerative lumbar spinal stenosis, were selected in the study. Patients were divided into two groups. Group A included all patients who were between 65 and 69years of age at the time of surgery. Group B included all patients who were at least 70years of age at the time of surgery. We reviewed medical history including preoperative American Society of Anesthesiologists[ASA] classification of physical status, anesthetic risk factor, operative time, estimated blood loss, transfusion requirements, hospital stay, operated level, and clinical outcome to look for comparisons between two age groups [$65{\sim}69$ and over 70years]. Results : In preoperative evaluation, mean anesthetic risk factor of patients was numerically similar between the groups. The American Society of Anesthesiologists classification of physical status was similar between two groups. There was no difference in operated level, operative time, estimated blood loss, hospital stay, and anesthetic risk factor between the two groups. The clinical successful outcome showed 82.7% for Group A and 81.8% for group B. The overall postoperative complication rates were similar for both group A and B. Conclusion : We conclude that advanced age per se, did not increase the associated morbidity and mortality in surgical decompression for spinal stenosis.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.657-673
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• 1992

Orthodontic treatment of cleft patients is difficult as the growth is different from that of normal ones. So it is very important to know the characteristic features of the craniofacial morphology and growth pattern in unilateral cleft lip and palate patients. The materials for this study consisted of 55 normal males and 50 unilateral cleft lip and palate ones who received cheiloplasty and palatoplasty previously. The cleft subjects were divided into 4 groups according to their ages kto find out the growth pattern of hard and soft tissue, and to compare the features with those of normal ones. Each cephalogram analysed by McNamara method and others. The obtained results were as follows 1. In the unilateral cleft lip and palate subjects, forward growth of the maxilla was smaller than that of normal ones from 9 years old. So the maxilla was retruded. The maxillary incisors were severely retruded in all age groups. 2. The mandibular overall length and its anteroposterior position did not show any significant differences between two groups. But the height of ramus was very short and the mandible had vertical growth tendency to compensate for undergrowth of the maxilla in cleft subjects after 12 years of age. 3. Horizontal growth of the soft tissue in middle face was smaller than that of any other facial region from 9 years old. The vertical growth rate of upper lip was decreased as growing old. 4. In cleft subjects, the upper and lower facial component angle and the facial convexity angle were large. So their facial profile changed to straight or concave as growing old.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.34-42
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• 2018

Purpose: Monogenic inflammatory bowel disease (IBD) patients do not respond to conventional therapy and are associated with a higher morbidity. We summarized the clinical characteristics of monogenic IBD patients and compared their clinical outcomes to that of non-monogenic IBD patients. Methods: We performed a retrospective cohort study of all children <18 years old who were diagnosed with IBD between 2005 and 2016. A total of 230 children were enrolled. Monogenic IBD was defined as a presentation age less than 6 years old with confirmation of a genetic disorder. We subdivided the groups into monogenic IBD (n=18), non-monogenic very early-onset IBD (defined as patients with a presentation age <6 years old without a confirmed genetic disorder, n=12), non-monogenic IBD (defined as all patients under 18 years old excluding monogenic IBD, n=212), and severe IBD (defined as patients treated with an anti-tumor necrosis factor excluding monogenic IBD, n=92). We compared demographic data, initial pediatric Crohn disease activity index/pediatric ulcerative colitis activity index (PCDAI/PUCAI) score, frequency of hospitalizations, surgical experiences, and height and weight under 3rd percentile among the patients enrolled. Results: The initial PCDAI/PUCAI score (p<0.05), incidence of surgery per year (p<0.05), and hospitalization per year (p<0.05) were higher in the monogenic IBD group than in the other IBD groups. Additionally, the proportion of children whose weight and height were less than the 3rd percentile (p<0.05 and p<0.05, respectively) was also higher in the monogenic IBD group. Conclusion: Monogenic IBD showed more severe clinical manifestations than the other groups.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3763-3766
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• 2014

Human mammary epithelial cells have different proliferative statuses and demonstrate a close relationship with age and cell proliferation. Research on this topic could help understand the occurrence, progression and prognosis of breast cancer. In this article, using significance analysis of a microarray algorithm, we analyzed gene expression profiles of human mammary epithelial cells of different proliferative statuses and different age groups. The results showed there were significant differences in gene expression in the same proliferation status between elderly and young groups. Three common differentially expressed genes were found to dynamically change with the proliferation status and to be closely related to tumorigenesis. We also found elderly group had less status-related differential genes from actively proliferating status to intermediate status and more statusrelated differential genes from intermediate status than the young group. Finally, functional enrichment analyses allowed evaluation of the detailed roles of these differentially-expressed genes in tumor progression.

• The Journal of the Korea Contents Association
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• v.20 no.7
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• pp.127-138
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• 2020

This study aims to analyze influences of self-perceived health, participation in social activities on life satisfaction and mediating effect of participation in social activities of the elderly by age group. For this, Structural Equation Model(SEM) was implemented by using data of the 6th wave of KLoSA with 2,106 young-olds and 2,219 old-olds. The results are as follows: The young-old elderly had higher level of self-perceived health, higher participation in social activities, and higher life satisfaction than the old-old elderly, and the mediating effect of participation in social activities was founded only in the young-old elderly. As a result of multi-group analysis, the influence of self-perceived health on life satisfaction was confirmed by no difference between both groups and the influence of self-perceived health on the participation in social activities was relatively higher in the old-old elderly. In the path of participation in social activities on the life satisfaction, the young-old elderly were found to have a significant effect. Through above results, the intervention plan considering the differences between groups was discussed in order to improve the elderly's life satisfaction.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.4
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• pp.307-315
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• 2022

Since attaining middle age, many patients suffer from the post-micturition dribble (PMD) syndrome but do not receive proper treatment. This is because the etiology and treatment mechanisms of PMD differ from conventional lower urinary tract symptoms. Several pathophysiologies have been proposed, but the mechanisms we observed are the weakening of the bulbocavernosus muscle and dilation of the urethra due to atrophy of the cavernosal tissue. This study investigates the mechanism of PMD by observing anatomical changes in the corpus cavernosum and urethra. SD male rats were categorized by age into the young rats group (8 weeks old) and the old rats group (24 months or more). The ratio area of the bulbous urethra and corpus cavernosum to the total penis was statistically significant between both groups (P<0.05). Significant differences were obtained between the two groups for restored smooth muscle contents and several other parameters related to PMD mechanisms (nNOS, α-SMA) (P<0.05). The changes in size and parameters of the urethra and corpus cavernosum in young and old rats were confirmed. The results from this study are expected to contribute to the study of PMD in the future.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.20 no.2
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• pp.79-86
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• 2017

Purpose: Congenital esophageal atresia (CES) is a rare congenital disease. The severity of symptoms is variable; thus, diagnosis is difficult and tends to be delayed. CES is frequently accompanied by esophageal atresia (EA) with/without tracheoesophageal fistula (TEF). We investigated the characteristics of CES by reviewing our experience with CES patients and researched the differences between CES with EA-TEF and isolated CES. Methods: A total of 31 patients underwent operations for CES were reviewed retrospectively. The patients were divided into two groups according to the association with EA-TEF, and compared the differences. Results: Sixteen boys and 15 girls were included. The mean age at symptom onset was 8 months old, and the mean age at diagnosis was 21 months old. Nine patients with EA-TEF were included group A, whereas the other 22 patients were assigned to group B. There were no differences in sex, gestational age, associated anomalies and pathologic results between the groups. In group A, the age at diagnosis and age at surgery were younger than in group B despite the age at symptom occurrence being similar. Postoperative complications occurred only in group A. Conclusion: In this study, symptoms occurred during the weaning period, and vomiting was the most frequent symptom. CES patients with EA-TEF tended to be diagnosed and treated earlier despite the age at symptom occurrence being similar. CES patients with EA-TEF had more postoperative complications; therefore, greater attention should be paid during the postoperative period.

• Journal of Veterinary Clinics
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• v.34 no.1
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• pp.27-33
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• 2017

Although HDACIs affect ubiquitously expressed histone deacetylase and increase cellular senescence, there has been little study on the effect of age on treatment with HDACIs. Accordingly, the purpose of this study was to compare cellular senescence status and vorinostat-induced senescence in fibroblasts derived from aged dogs compared to young dogs. Skin tissues were taken from young (1-year-old) and aged (7-year-old) male dogs, and fibroblasts were cultured without (control) or with 10 uM of vorinostat for 24 hr. Beta-galactosidase activity was assessed, and real-time polymerase chain reaction and western blotting were performed to analyze the expression levels of transcripts and proteins related to cellular senescence. Beta-galactosidase activity was higher in aged dogs compared to young dogs in the control group, and was increased by vorinostat treatment. Expression of p21, p53 and p16 transcripts was higher in the aged than in the young group, and all transcripts were affected by vorinostat in both young and aged groups. Western blot results showed lower H3K9 acetylation in the aged dogs compared to the young dogs, and the acetylation was increased by vorinostat treatment in both groups. However, there was no significant difference between the transcript or protein alterations induced by vorinostat.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.256-259
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• 2005

Analysis of behavior pattern and thermal response during bathing and showering provides important fundamental data when developing an automatic bathing/showering system. The behavior pattern and physiological changes during bathing/showering were measured und analyzed for the aged male group. We recorded the volunteers showering at front, back, left and right view using four CCTV cameras in order to study the behavior pattern during showering. The photographic data were analyzed by counting the frequencies of body contact and identifying zones where hands could reach. In order to study the thermal response, we measured the blood pressure (B.P), heart rate (H.R), body temperature (B.T.), breathing rate (B.R) for the different water temperatures and the locations of immersion for the young and old age groups. The results showed that the frequencies of body contacts were varied for different body sections. Also there were some body sections where hands could not be reached because of reduced pliability and muscular strength of the aged group. But we observed rather uniform body contact frequencies when a towel was used. In partial immersion bath experiments, we observed the changes of B.P. H.R and B.T in the case of young and old age groups, and the changes were more significant in the young age group.