• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권2호
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• pp.173-182
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• 2005

소아기 발병 정신분열병(COS)은 비록 흔하지는 않지만 성인 발병 정신분열병에 비해 보다 동질적인 집단이며 질병의 진행과정을 추적할 수 있다는 면에서 정신분열병 연구자들의 관심의 대상이 된다. COS 환자에대한 기존의 연구 결과들은 소아에서도 성인 진단기준에 의거한 구조적면담을 통해 객관적으로 타당성 있는 정신분열병 진단이 가능하다는 것이다. 또한 소아와 성인 발병 정신분열병이 동일한 임상양상과 질병 진행과정을 보이며 생물학적 여러분야(신경심리, 신경생리, 뇌 구조, 뇌 생화학, 유전 및 염색체)의 연구결과들 역시 성인 발병 정신분열병과 동일한 소견을 보인다는 것이다. 다만 차이점은 COS의 경우 치료 약물반응이 상대적으로 떨어지고, 임상경과 및 예후가 나쁘고, 발병전 발달(언어, 인지, 섬세운동)에 문제가 심각하고, 염색체 이상, 정신분열병이나 정신분열병 스펙트럼 장애의 가족력이 흔하여 유전적 부하가 높다는 것이다. 향후 COS 환자를 대상으로한 유전연구 및 뇌발달 영상 추적연구는 정신분열병의 뇌 신경발달에 관한 기초적인 지식을 확대시킬 것이다. 즉 뇌 발달을 조절하는 유전자의 기능과 발현 시기에 대한 좀 더 명확한 지식을 제공할 것이며 이를 토대로한 위험군에 대한 조기발견 및 치료방안이 강구되어야 하겠다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권1호
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• pp.133-138
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• 1997

Prader-Willi 증후군(Prader-Willi Syndrome, PWS)은 $50{\sim}-70%$ 정도의 환자에서 염색체 15번에 이상이 있음이 보고된 유전적인 질환으로서, 그 특징적인 임상양상은 심한 근긴장의 저하(hypotonia), 반사소실(areflexia), 섭식의 곤란(feeding difficulty), 저체온증(hypothermia), 성기왜소증(microgenitalia), 음낭저형성증(hypoplastic scrotum), 대식증(polyphagia), 포만감의 감소와 비만, 정신운동발달의 지연, 저성선기능증(hypogonadism) 및 안면과 척추의 기형 등이다. 또한 행동상의 여러 문제들이 동반되는데 분노발작, 피부를 심하게 뜯거나 발모광, 과도한 식욕과 관련된 음식 도벽증이 나타나므로 정신과적 치료가 필요하다. 본 증례는 14세된 PWS환자로서 비만과 대식증, 도벽증, 학업부진 및 생활부적응 문제 등으로 2주간의 입원과 약 1년간의 추적기간 동안 약물요법(fluoxetine 투여)과 행동요법, 그리고 가족요법을 받아 왔다. 장기간의 Fluoxetine투여를 통하여 비만과 식욕의 조절에는 효과가 만족스럽지 않았으나 우울감과 감정문제, 자살사고 및 행동문제들은 호전되었다.

• Clinical and Experimental Pediatrics
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• 제59권10호
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• pp.421-424
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• 2016

Recurrent macrophage activation syndrome (MAS) is very rare. We present the case of an adolescent boy with human leukocyte antigen (HLA) B27-positive ankylosing spondylitis (AS), who experienced episodes of recurrent MAS since he was a toddler. A 16-year-old boy was admitted because of remittent fever with pancytopenia and splenomegaly after surgical intervention for an intractable perianal abscess. He had been diagnosed with hemophagocytic lymphohistiocytosis (HLH) 4 different times, which was well controlled with intravenous immunoglobulin and steroids since the age of 3. We were unable to identify the cause for the HLH. He remained symptom-free until the development of back pain and right ankle joint pain with swelling at 15 years of age. He was diagnosed with HLA B27-positive AS with bilateral active sacroiliitis. He showed symptom aggravation despite taking naproxen and methotrexate, and the symptoms improved with etanercept. On admission, his laboratory data showed leukopenia with high ferritin and triglyceride levels. Bone marrow biopsy examination showed histiocytic hyperplasia with hemophagocytosis. There was no evidence of infection. He received naproxen alone, and his symptoms and laboratory data improved without any other immunomodulatory medications. Genetic study revealed no primary HLH or inflammasome abnormalities. In this case, underlying autoimmune disease should have been considered as the cause of recurrent MAS in the young patient once primary HLH was excluded.

• 한국산학기술학회논문지
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• 제13권7호
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• pp.3074-3084
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• 2012

본 연구의 목적은 청소년기 특발성 척추측만증 환자를 대상으로 슬링을 이용한 요부안정화 운동프로그램이 정적 선 자세의 균형에 미치는 영향을 알아보고자 하였다. 본 연구의 대상자는 특발성 척추측만증을 진단 받은 환자 40명을 무작위로 두군으로 나눈 후 실험군(n=20)은 슬링 요부안정화 운동, 대조군(n=20)은 단지 자세교육만 실시하였다. 두군 모두 실험 전 후 균형 수행 모니터(Balance performance monitor)을 이용하여 눈을 감은 상태에서의 양발서기 자세와 눈을 뜬 상태에서의 양발서기에서 동요거리(총, 좌우방향, 전후방향)와 동요속도(총, 좌우방향, 전후방향)를 측정하였다. 운동프로그램 적용 후에 두그룹간에 모든 변수에서 유의한 차이를 보였다. 실험군은 운동 전 후 모든 변수에서 유의한 감소를 보였다. 그러나 대조군에서는 유의한 차이를 보이지 않았다. 이상의 결과를 통해서 슬링 요부안정화 운동프로그램은 특발성 척추측만증 환자의 체중심 동요거리와 동요속도를 감소시켜 정적 선 자세 균형능력을 향상시켰으며 슬링 요부안정화 운동프로그램이 청소년기 특발성 척추측만증 환자의 균형 증진 중재가 될 수 있을 것으로 보인다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권3호
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• pp.174-181
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• 2010

Objectives: To identify the factors affecting long-term adherence to methylphenidate treatment in children with attention-deficit hyperactivity disorder (ADHD). Methods: A retrospective medical record review of 239 ADHD patients (mean age $9.3{\pm}2.6$ years, range 6.0-17.4 years) who had visited the child and adolescent psychiatry clinic at a university hospital, in Seoul, Korea from March 2005 to February 2008. Subjects were diagnosed as ADHD based on the criteria set forth in the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision version (DSM-IV-TR) and underwent neuropsychological tests including the continuous performance test (CPT). Treatment discontinuation was defined as the last prescription date when the medication possession rate (MPR) became less than 0.80. Subjects were divided into three groups and labeled as Group I, non-adherence without pharmacotherapy, Group II, non-adherence with short-term pharmacotherapy, and Group III, adherence with long-term pharmacotherapy. Results: Ninety (37.7%) patients were grouped as non-adherent (Groups I+II) and 149 (62.3%) as adherent (Group III). The adherence group exhibited lower intelligence, higher symptom severity, and a higher number of comorbid psychiatric disorders than controls. The use of stimulants was significantly associated with long-term adherence to treatment. Additionally, the duration of interval between the date of the first visit and the date of the first prescription was positively associated with long-term adherence. Conclusion: About two-thirds of patients diagnosed as ADHD adhered to the treatment six months after the first visit. With respect to patient evaluation and the development of treatment strategies, factors affecting early drop-out and longer follow-up must be considered.

• Journal of Oral Medicine and Pain
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• 제34권3호
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• pp.277-294
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• 2009

본 연구의 목적은 II급 청소년, 성인 환자에서 발치와 비발치 후 연조직 변화를 비교하기 위한 것이었다. 원광대학교 치과병원 교정과에 내원한 환자 68명을 각각 청소년발치군, 청소년비발치군, 성인발치군, 성인비발치군으로 분류하여 치료 전후의 측모 두부방사선사진을 계측하였다. 각 군의 치료 전후를 비교하고 각 군 간의 변화량을 비교하였으며, 그 중 통계적으로 유의한 변수들의 상관성과 회귀분석을 하여 다음과 같은 결과를 얻었다. 청소년과 성인의 발치군에서 비순각은 유의하게 증가하였고 비발치군에서는 유의하게 감소하였다. 발치군에서는 vertical-U1과 E line-upper lip의 변화량 간에, vertical-U1과 E line-lower lip의 변화량 간에, vertical-L1과 vertical-Li의 변화량 간에 양의 상관관계를 보였다. 또한 발치군에서 회귀분석을 통해 E line-upper lip, E line-lower lip, Li에 대한 단순회귀방정식이 도출되었다.

• 대한임상독성학회지
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• 제17권1호
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• pp.38-41
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• 2019

Procalcitonin (PCT) is commonly employed in medical practice as a diagnostic biomarker of bacterial infection and also as a monitoring biomarker for antimicrobial therapy. There have been a few published reports concerning elevated PCT levels in people with acute liver injury caused by an overdose of acetaminophen. We report here on a case of PCT elevation in an adolescent with acute acetaminophen poisoning without any bacterial infection or liver injury. A 15-year-old girl had deliberately ingested 20 tablets of 650 mg acetaminophen (13 g) and she presented to our emergency department. The PCT level on admission was elevated to 65.64 ng/mL (reference range: 0-0.5 ng/mL). Her PCT level on the second day peaked up to 100 ng/mL and then it gradually decreased. There was no evidence of liver injury or infection on the computed tomography examination and other lab tests. The patient regained her good health and was discharged on the sixth day of hospitalization.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제30권1호
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• pp.2-8
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• 2019

Objectives: This study aimed to compare the quality of life reported by patients with attention-deficit/hyperactivity disorder (ADHD) to the patients' quality of life as reported by their caregivers. In addition, it aimed to examine how emotional problems, including depression and anxiety, and the severity of the symptoms affect the quality of life reported by the patients and their caregivers. Methods: The patients' quality of life and their degree of depression and anxiety were measured using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Child Self-Report, the Children's Depression Inventory (CDI), and the Revised Children's Manifest Anxiety Scale, respectively. The caregivers' perception of the patients' quality of life and severity of the ADHD symptoms were measured using the PedsQL 4.0 Parent Proxy Report and the Conners' Parent Rating Scale (CPRS), respectively. A total of 66 participants completed the survey. The independent-samples t-test, Pearson's correlation analysis, and multiple regression analysis were conducted. Results: The mean score of the PedsQL 4.0 Child Self-Report was significantly higher than the mean score of the PedsQL 4.0 Parent Proxy Report. However, for school function, the PedsQL 4.0 Child Self-Report score was significantly lower than that of Parent Proxy Report. The correlation between the PedsQL 4.0 Child Self-Report and PedsQL 4.0 Parent Proxy Report scores was significant only for emotional function and social function. The multiple regression analysis showed that the PedsQL 4.0 Child Self-Report and PedsQL 4.0 Parent Proxy Report scores were significantly predicted by the CDI and CPRS scores, respectively. Conclusion: Our results demonstrate that there are clear differences between the quality of life reported by the patient themselves and that reported by their caregivers. In addition, the findings suggest that it is critical to treat the patients' accompanying depressive symptoms.

• 대한소아치과학회지
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• 제23권4호
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• pp.840-858
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• 1996

The main purpose of this study was to evaluate the anticariogenic effect of argon laser. Histological observations on lesion initiation and progression were performed under the polarized microscope. The results from the present study can be summarized as follows; 1. The specimens of laser cured group were shown to have more irregular and discontinuous lesion body in general than visible light cured group with rather continuous positive birefringence. 2. With lesion initiation and progression, almost all the specimens showed deeper body of lesion with shallower intact surface zone in the visible light cured group than the laser cured group(p<0.05). When the comparision was made between the two argon laser cured groups, the single-cure group showed deeper lesion body and the shallower surface layer than double-cure group. 3. Based upon the above mentioned results of this study, it can be assumed that the use of argon laser in the procedure of resin polymerization may provide the child and adolescent patient population with anticariogenic effect as well as efficient polymerization. Further studies using various materials and experimental conditions are being encouraged.

• 대한불안의학회지
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• 제8권2호
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• pp.161-166
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• 2012

Though infanticide, killing the baby after birth of the neonate and denial of pregnancy, are very rare psychiatric disorder, they have been receiving a lot of social concerns. We report and review infanticide and denial of pregnancy administration in a 19 year-old adolescent with bipolar disorder and borderline personality disorder. Patients with a young age, cognitive immaturity, an unwanted child, hid the pregnancy facts were consistent with the results of previous studies. In addition, the patient's impulsivity and emotional instability is affecting infanticide. After inpatient care with pharmacotherapy (escitalopram 20mg, alprazolam 1.5 mg, clonazepam 0.5 mg, valproate sodium 1,100-1,300 mg, and quetiapine 100-400 mg) and supportive psychotherapy, and there were significant improvement of clinical symptoms.