• 제목/요약/키워드: yield potential

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Cinmetacin의 amide 유도체 합성과 항염진통활성 (Synthesis and Antiinflammatory-analgesic Activity of Cinmetacin Amides)

  • 임채욱;홍용기;임철부
    • 약학회지
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    • 제45권6호
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    • pp.565-569
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    • 2001
  • Five novel cinmetacin amide derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiinflammatory-analgesic activity was compared with cinmetacin. Cinmetacin and hydroxysuccinimide were reacted with dicyclohexyl carbodiimide to give cinmetacin active ester (4), which was treated with amines to yield cinmetacin amides (5-9). Compounds (5) and (9) gave stronger analgesic activity than cinmetacin and compounds (5), (6), (9) showed comparable antiinflammatory activity to cinmetacin.

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Cinmetacin유도체의 합성과 진통항염활성 (Synthesis and Analgesic-antiinflammatory Activity of Cinmetacin Derivatives)

  • 임채욱;이종민;유재학;이현수;임철부
    • 약학회지
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    • 제45권1호
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    • pp.1-6
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    • 2001
  • Nine cinmetacin derivatives as potential nonsteroidal analgesic and antiinflammatory compounds were prepared and their analgesic-antiinflammatory activity was compared with cinmetacin. Salicylic acid and phenols were reacted with dicyclohexyl carbodiimide (DCC) to give phenol salicylates (1-4). Cinmetacin was treated with DCC and phenol derivatives to yield cinmetacin esters (5-13). Compounds (5, 7, 8, 10, 12, and 13) showed stronger analgesic activity than cinmetacin, but only compound (5) showed comparable antiinflammatory activity to cinmetacin.

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실리콘 광 촉매 연구동향 (Recent progress in silicon photocatalyst)

  • 이민우;심우영
    • 세라미스트
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    • 제23권2호
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    • pp.178-183
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    • 2020
  • Solar energy conversion is now actively researching because of pollution. Especially silicon photocatalyst has big potential, because of wide absorption range. But low quantum yield of silicon photocatalyst can't be used for commercialization. This paper summarize mechanism of silicon photocatalyst. In addition, properties and current states of photo catalyst using nanomaterials of silicon are also introduced.

A Convenient Synthesis of an Anti-Helicobacter Pylori Agent, Dehydrodiconiferyl Alcohol

  • Hu, Kun;Jeong, Jin-Hyun
    • Archives of Pharmacal Research
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    • 제29권7호
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    • pp.563-565
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    • 2006
  • Potential anti-Helicobacter pylori agent dehydrodiconiferyl alcohol was synthesized in 44% overall yield, starting from vanillin which could be commercially available. Carbon extension of vanillin followed by the Horner-Wadsworth-Emmons reaction, a biomolecular radical coupling reaction and DIBAL-H reduction gave dehydrodiconiferyl alcohol.