• 생약학회지
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• 제33권1호통권128호
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• pp.45-48
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• 2002

Zanthoxyli Fructus has been used in traditional medicine for the treatment of analgesic, gastric disorder, rheumatism etc. In order to evaluate the quality of Zanthoxyli Fructus, the method of isolation and quantitative determination of xanthoxylin as a standard compound has been developed. The HPLC method, using the mobile phase of acetonitrile-water (4:6), showed that the amount of xanthoxylin wεre in the rangε of 0.01 to 2.67%.

• 생약학회지
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• 제50권3호
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• pp.159-164
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• 2019

Zanthoxylum Peel is widely used as a common spice for a variety of foods. In the orient, it has also been used as traditional agents for treating diseases such as indigestion. Recently, Zanthoxylum Peel has been reported to have anti-cancer activity, anti-microbial activity, and anti-inflammatory activity. Chemical components are known sanshool compounds and xanthoxylin. In this study, we were carried out to investigate the constituents of inhibiting a drug metabolizing enzyme CYP3A4 from Zanthoxylum Peel. CYP3A4 is known as an enzyme involved in drug metabolism as monooxygenase containing the heme. As a result of experiment, we found that bergapten ($IC_{50}=18.21{\mu}M$) and quercetin ($IC_{50}=17.27{\mu}M$) isolated from EtOAc extract of Zanthoxylum Peel showed remarkable CYP3A4-inhibiting activities. Structures of the isolated active compounds were established by chemical and spectroscopic means.