• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2003년도 춘계학술대회 논문집
• /
• pp.58-58
• /
• 2003

Aflatoxins are metabolites of fungi Aspergillus spp. that world-widely contaminate diverse foodstuffs including com and peanuts. It is well known that aflatoxins are highly mutagenic, carcinogenic and possibly teratogenic. Although aflatoxins have received the great attention among the various mycotoxins due to their potent hepatocarcinogenicity in certain species, it is extremely crucial to elucidate the relative toxicity and carcinogenicity of the types (B$_1$, B$_2$, G$_1$ and G$_2$) of aflatoxins for the risk assessment.(omitted)

• 한국환경보건학회지
• /
• 제41권6호
• /
• pp.425-437
• /
• 2015

Objectives: Risk assessment is a tool for predicting and reducing uncertainty related to the effects of future activities. Probability approaches are the main elements in risk assessment, but confusion about the interpretation and use of assessment factors often undermines the message of the analyses. The aim of this study is to provide a guideline for systematic reduction plans regarding uncertainty in risk assessment. Methods: Articles and reports were collected online using the key words "uncertainty analysis" on risk assessment. Uncertainty analysis was conducted based on reports focusing on procedures for analysis methods by the World Health Organization (WHO) and U.S. Environmental Protection Agency (USEPA). In addition, case studies were performed in order to verify suggested methods qualitatively and quantitatively with exposure data, including measured data on toluene and styrene in residential spaces and multi-use facilities. Results: Based on an analysis of the data on uncertainty, three major factors including scenario, model, and parameters were identified as the main sources of uncertainty, and tiered approaches were determined. In the case study, the risk of toluene and styrene was evaluated and the most influential factors were also determined. Five reduction plans were presented: providing standard guidelines, using reliable exposure factors, possessing quality controls for analysis and scientific expertise, and introducing a peer review system. Conclusion: In this study, we established a method for reducing uncertainty by taking into account the major factors. Also, we showed a method for uncertainty analysis with tiered approaches. However, uncertainties are difficult to define because they are generated by many factors. Therefore, further studies are needed for the development of technical guidelines based on the representative scenario, model, and parameters developed in this study.

• 한국임상수의학회지
• /
• 제32권1호
• /
• pp.78-84
• /
• 2015

Although researches have highlighted the important role of enhanced farm biosecurity to reduce the severity and prevalence of diseases in livestock, to date there has been little study in Korea on farmers' adoption of biosecurity measures to control porcine reproductive and respiratory syndrome virus (PRRSV) infection. To mitigate the risk of PRRSV infection in pigs, the risk factors by which PRRSV is introduced in pig farms must be determined. The primary aim of this study was to investigate pig producers' perceptions about on-farm biosecurity practices. We also analyzed data obtained from a cross-sectional study on 196 farrow-to-finish farms conducted between March 2013 and February 2014 to identify risk factors for PRRSV infection at farm level. Standardized questionnaires with information about basic demographical data and management practices were collected in each farm by on-site visit of trained veterinarians. Farms were classified as negative or positive through the use of infection profiles that combined data on PCR positive pigs and serological testing including antibody titer, sero-conversion pattern at each age category, and vaccination status. Data on biosecurity practices, farm management and environmental characteristics were analyzed using multivariate ordinal logistic regression. Generally, the biosecurity level in the pig farms included in this study were insufficient to reduce/prevent the risk of PRRSV infection given the high pig density areas and the considerable extent of vehicle movement. Factors associated with PRRSV infection were those where owners used on-farm vaccination programs had a lower risk of infection (OR = 0.19, 95% CI 0.06-0.61). The results from the analysis may guide to tailor biosecurity measures in the reduction or prevention of PRRS to the specific circumstances of pig farms in different localities of the world. To the best knowledge of the authors, this is the first study to report information on the biosecurity practices currently implemented on Korean pig farms.

• 대기
• /
• 제30권2호
• /
• pp.195-207
• /
• 2020

This study aims to introduce the structure of the impact-based heat health warning system on 165 counties in South Korea developed by the National Institute of Meteorological Sciences. This system was developed using the daily maximum perceived temperature (PTmax), which is a human physiology-based thermal comfort index, and the Local ENSemble prediction system for the probability forecasts. Also, A risk matrix proposed by the World Meteorological Organization was employed for the impact-based forecasts of this system. The threshold value of the risk matrix was separately set depending on regions. In this system, the risk level was issued as four levels (GREEN, YELLOW, ORANGE, RED) for first, second, and third forecast lead-day (LD1, LD2, and LD3). The daily risk level issued by the system was evaluated using emergency heat-related patients obtained at six cities, including Seoul, Incheon, Daejeon, Gwangju, Daegu, and Busan, for LD1 to LD3. The high-risks level occurred more consistently in the shorter lead time (LD3 → LD1) and the performance (r_s) was increased from 0.42 (LD3) to 0.45 (LD1) in all cities. Especially, it showed good performance (r_s = 0.51) in July and August, when heat stress is highest in South Korea. From an impact-based forecasting perspective, PTmax is one of the most suitable temperature indicators for issuing the health risk warnings by heat in South Korea.

• 한방비만학회지
• /
• 제4권1호
• /
• pp.33-43
• /
• 2004

Background: Recently obesity has become a social problem in all over the world including Korea. It is known that obesity is closely related with cardiovascular disease. Many studies are carrying out in the relation between several obesity indices, such as body mass index(BMI), waist-circumference(WC), body fat percent and risk factors of cardiovascular disease. Objective: This study was done in order to investigate correlation of obesity and cardiovascular risk factors. Method: We gathered totally 138 subjects who have taken health screening test in university hospital. With the exception of 40 abnormal cases on current illness and laboratory study, 98 healthy cases were analysed. We divided the groups as normal, overweight, obese group according to body mass index $(22.9kg/m^2\;and\;below\;/\;23{\sim}24.9kg/m^2\;/\;25kg/m^2\;and\;above)$and investigated the relationship between obesity based on body mass index(BMI) and cardiovascular risk factors. And investigated the relationship between each cardiovascular risk factor and body mass index, waist-hip ratio, body fat percent. Results: With the exception of blood pressure, other lab data such as total cholesterol, triglycerid, glucose were significantly different between the three groups divided by body mass index$(22.9kg/m^2\;and\;below\;/\;23{\sim}24.9kg/m^2\;/\;25kg/m^2\;and\;above)$. And Correlation coefficient of cardiovascular risk factors with body mass index, waist-hip ratio, body fat precent were acquired. Conclusion: We have concluded that the body mass index and waist-hip ratio body fat precent were predictive factors cardiovascular disease.

• 항공우주시스템공학회지
• /
• 제12권5호
• /
• pp.76-88
• /
• 2018

미 항공우주국(NASA), 유럽우주기구(ESA) 등의 우주기관 및 미국 군에서는 제품보증 수행에 대한 요구조건 및 계획 등에 대한 가이드라인 또는 표준서를 제시하고 있다. 최근 들어, 세계의 주요 위성제작사는 테일러링(tailoring)을 통해 과도한 제품보증 요구조건 및 프로세스를 완화하고 있다. 비용 및 일정의 효율성을 증진시키기 위한 테일러링을 수행한다는 의미이다. 제품보증 테일러링은 임무, 임무 리스크의 유형, 복잡도, 개발비용 및 수명주기 등의 다양한 인자를 기준으로 수행될 수 있다. 본 연구에서는 NASA에서 제안된 임무 리스크(mission risk) 분류에 따른 제품보증 업무를 조사하고, 개발비용 및 일정의 최적화를 위한 테일러링 방안을 제시한다. 특히, 국내에서 개발하여 운용 중이거나 개발 중인 위성에 대한 임무 리스크 유형을 정의하고 이들에 대한 제품보증 특성을 비교 분석한다.

• Annals of Occupational and Environmental Medicine
• /
• 제35권
• /
• pp.3.1-3.11
• /
• 2023

Background: Studies on the risk of mercury (Hg) in Korean fishery products focus primarily on total Hg levels as opposed to methylmercury (MeHg) levels. None of the few studies on MeHg in tuna investigated tuna from Japanese restaurants. Few have evaluated lead (Pb), cadmium (Cd) and arsenic (As) in tuna. Thus, this study aimed to conduct a risk assessment by evaluating heavy metal concentrations in tuna from Japanese restaurants. Methods: Thirty-one tuna samples were collected from Japanese restaurants in the Republic of Korea. They were classified according to region and species. The concentration of heavy metals in the samples was analyzed using the Ministry of Food and Drug Safety Food Code method. The rate of exceedance of maximum residue levels (MRLs) and the risk compared to the provisional tolerable weekly intake (PTWI) set by the Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives (%PTWI) were evaluated for risk assessment. Results: The mean of MeHg, Pb, Cd and As concentrations were 0.56 ± 1.47 mg/kg, 33.95 ± 3.74 ㎍/kg, 14.25 ± 2.19 ㎍/kg and 1.46 ± 1.89 mg/kg, respectively. No sample exceeded the MRLs of Pb and Cd, but 9.7% of the samples exceeded the MRL of MeHg. The %PTWIs of MeHg, Pb, Cd and As were 4.2037, 0.0162, 0.0244 and 1.1627, respectively. The %PTWI of MeHg by age group and sex was highest among men aged 19-29 years (10.6494), followed by men aged 30-49 years (7.2458) and women aged 19-29 years (4.8307). Conclusions: We found that 3 out of 31 samples exceeded the MRL of MeHg. The %PTWI of MeHg showed significant differences based on age and sex, and the value was likely to exceed a safe level depending on individuals' eating behaviors. Therefore, improved risk management for MeHg is required.

• 한국경영과학회지
• /
• 제22권3호
• /
• pp.175-190
• /
• 1997

Organizational change projects such as Business Process Redisign (BPR) have been perceived to incur high risk due to their high management complexity, enterprise-wide impace, and steep project cost. This research intends to reduce such risk by developing a systematic process redesign methods, called Dynamic Process Modeling (DPM) method. DPM integrates the customer-oriented business process modeling technique with computerized visual simulation technique to promote better understanding of the target process and enable performance simulation of the proposed redesign alternatives prior to actual BPR implementations. For the cusstomer-oriented process modeling, we propose Dynamic-Event Process Chain (Dynamic-EPC) extending from the conceptual customer process model, Event-Process Chain (EPC). We compare DPM with four other implementation-level process modeling methods over eight criteria and demonstrate its effectiveness by applying it to the real-world hospital BPR case.

• 시스템엔지니어링학술지
• /
• 제4권1호
• /
• pp.19-29
• /
• 2008

Traditionally gas plant R&D has had a world-wide weak position in terms of high technology. Especially System engineering did not exactly apply to gas plant construction. So, Gas Plant R&D Center is determined to make the establishment of the system engineering for the standard of gas plant. Gas Plant R&D Center has two projects. Firstly, the establishment of the R&D management system. Secondly, the system engineering which is included in the VE concept of EPC parts. But Gas Plant R&D Center exists in the particular conditions for successful development of the new process and core equipments. Now we will describe the establishment of R&D management system and particular conditions(Risk Conditions) for gas plant.

• 한국산학기술학회논문지
• /
• 제4권3호
• /
• pp.189-192
• /
• 2003

본 논문에서는 대재해채권의 개념과 장단점, 필요성, 그리고 우리나라에서 발생가능성에 대해서 연구하였다. 우리나라도 급변하는 금융환경하에서 대재해채권과 같은 새로운 금융상품에 대해서 연구할 필요가 있다. 대재해채권은 보험시장과 자본시장의 상이한 요구조건을 동시에 충족시켜줄 수 있는 새로운 혁신적인 금융상품이다. 우리나라의 보험시장과 자본시장도 세계 시장의 조류에 발 맞추어 대재해채권에 대한 관심 및 투자가 필요한 시기이다.