• Proceedings of the PSK Conference
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• 2001.10a
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• pp.222.3-223
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• 2001

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.164.2-164.2
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• 2001

• The International Journal of Costume Culture
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• v.3 no.1
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• pp.61-68
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• 2000

In recognition of the necessity to research on dresses of the past to lead future fashion, this study is focused on plastron basque that has constructed or decorated upper garments in various forms from the ancient times to modern times. Especially through reproduction and restoration of Victorian dress with plastron basque, the study approaches the problem in positive manner, As a result, studied 1887∼9 day dress is a plastron of pouched style with pleats panel in front center connected to jacket style bodice by buttons: and it shows changes into modern day dress form by constructing fitted line with decorative effects. By actually making the plastron that was only seen in picture, we expect this study will be a valuable resource for developing patterns, sewing and decoration techniques.

• Proceedings of the Costume Culture Conference
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• 1998.09a
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• pp.48-49
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• 1998

• Journal of Preventive Medicine and Public Health
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• v.52 no.3
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• pp.154-160
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• 2019

Objectives: Stillbirth is a common adverse pregnancy outcome that represents a distressing and traumatic event for women and their partners. The aim of this study was to identify factors associated with stillbirth in ever-pregnant women in Nepal. Methods: This study utilized the individual women's dataset from the Nepal Demographic and Health Survey, conducted in 2016. The dependent variable of interest was whether women had at least 1 stillbirth during their lifetime. The associations between independent variables and the dependent variable of the study were analyzed using a multiple logistic regression model. Results: Among 8918 ever-pregnant women aged 15-49 years, 488 had experienced at least 1 stillbirth during their lifetime, representing 5.5% of the total. After adjusting each factor for the confounding effects of other factors, maternal age, maternal education, place of residence, and sub-region remained significantly associated with having experienced stillbirth. Conclusions: Stillbirth continues to be a major problem among women, especially those with higher maternal age, those who are illiterate, and residents of certain geographical regions. To minimize stillbirth in Nepal, plans and policies should be focused on women with low education levels and residents of rural areas, especially in the western mountain and far-western hill regions.

• Proceedings of the Costume Culture Conference
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• 2000.09a
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• pp.36-37
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• 2000

• BMB Reports
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• v.45 no.3
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• pp.189-193
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• 2012

Cyst formation is a major characteristic of ADPKD and is caused by the abnormal proliferation of epithelial cells. Renal cyst formation disrupts renal function and induces diverse complications. The mechanism of cyst formation is unclear. mIMCD-3 cells were established to develop simple epithelial cell cysts in 3-D culture. We confirmed previously that Mxi1 plays a role in cyst formation in Mxi1-deficient mice. Cysts in Mxi1 transfectanted cells were showed by collagen or mebiol gels in 3-D cell culture system. Causative genes of ADPKD were measured by q RT-PCR. Herein, Mxi1 transfectants rarely formed a simple epithelial cyst and induced cell death. Overexpression of Mxi1 resulted in a decrease in the PKD1, PKD2 and c-myc mRNA relating to the pathway of cyst formation. These data indicate that Mxi1 influences cyst formation of mIMCD-3 cells in 3-D culture and that Mxi1 may control the mechanism of renal cyst formation.

• Genomics & Informatics
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• v.10 no.1
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• pp.16-22
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• 2012

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of multiple fluid-filled cysts that expand over time and destroy renal architecture. The proteins encoded by the $PKD1$ and $PKD2$ genes, mutations in which account for nearly all cases of ADPKD, may help guard against cystogenesis. Previously developed mouse models of $PKD1$ and $PKD2$ demonstrated an embryonic lethal phenotype and massive cyst formation in the kidney, indicating that $PKD1$ and $PKD2$ probably play important roles during normal renal tubular development. However, their precise role in development and the cellular mechanisms of cyst formation induced by $PKD1$ and $PKD2$ mutations are not fully understood. To address this question, we presently created $Pkd2$ knockout and $PKD2$ transgenic mouse embryo fibroblasts. We used a mouse oligonucleotide microarray to identify messenger RNAs whose expression was altered by the overexpression of the $PKD2$ or knockout of the $Pkd2$. The majority of identified mutations was involved in critical biological processes, such as metabolism, transcription, cell adhesion, cell cycle, and signal transduction. Herein, we confirmed differential expressions of several genes including aquaporin-1, according to different $PKD2$ expression levels in ADPKD mouse models, through microarray analysis. These data may be helpful in $PKD2$-related mechanisms of ADPKD pathogenesis.

• BMB Reports
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• v.40 no.2
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• pp.277-285
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• 2007

PCD (programmed cell death) is important mechanism for development, homeostasis and disease. To analyze the gene expression pattern in brain cells undergoing PCD in response to serum deprivation, we analyzed the cDNA microarray consisting of 2,300 genes and 7 housekeeping genes of cortical cells derived from mouse embryonic brain. Cortical cells were induced apoptosis by serum deprivation for 8 hours. We identified 69 up-regulated genes and 21 down-regulated genes in apoptotic cells. Based on the cDNA microarray data four genes were selected and analyzed by RT-PCR and northern blotting. To characterize the role of UNC-51-like kinase (ULK2) gene in PCD, we investigated cell death effect by ULK2. And we examined expression of several genes that related with PCD. Especially GAPDH was increased by ULK2. Theses findings indicated that ULK2 is involved in apoptosis through p53 pathway.

• Journal of Korean Academy of Nursing
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• v.37 no.5
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• pp.684-692
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• 2007

Purpose: The purpose of this study was to compare the effects of an exercise program on physical fitness, obesity indices, and blood lipids in cases of non-obese and obese women. Method: Data was collected from May, 2006 to November, 2006 in a public health center. All Subjects(37 women) participated in an exercise program that consisted of Latin dance, muscular strength training, and dumbbell exercises. Thirty-seven women were divided into two groups(16 non-obese women and 21 obese women) by %body fat. After 8 weeks, the effects of treatment were compared between pre-test and post-test in each group. Results: Physical fitness(abdominal muscle strength, muscle endurance, flexibility, agility, balance) was significantly different between the pre-test and post-test in the non-obese and obese group. Obesity indices(body weight, BMI) was significantly different in obese women after the 8-week exercise program. There was no decrease of blood lipids in either group. Conclusion: These findings indicate that an exercise program could be an effective nursing intervention to increase physical fitness in non-obese and obese women and to decrease obesity indices(body weight, BMI) in obese women.