• 대한임상독성학회지
• /
• 제19권1호
• /
• pp.31-37
• /
• 2021

Purpose: Acetaminophen (APAP) is a widely available drug responsible for a large part of drug-induced hepatotoxicity in developed countries. Although acetaminophen overdose cases in Korea are being continuously reported, there are no reports related to the level of this drug in the patient's blood or of laboratory analysis at emergency departments (ED). This study sought to analyze the acetaminophen overdose cases at a toxicological laboratory and to survey APAP analysis services offered at select EDs. Methods: We analyzed the demographic and analytic data at a toxicological laboratory run by the National Emergency Medical Center (NMC) in 2019-2020. We surveyed the APAP laboratory service in the 38 regional emergency medical centers (EMCs) and 68 local EMCs near the toxicological laboratory. Results: We studied 175 acute poisoning cases (112 women) with positive blood APAP results (mean age 47.0±24.1 years). Suicide attempts comprised 40.0% of the cases and 30.3% APAP overdose events. In the univariate analysis, we observed that patients were significantly younger, with fewer underlying medical diseases. There were a higher number of APAP overdose events, more favorable initial mental status, more toxic quantity intake in the above treatment line group (p<0.05), In multivariate analysis, the toxic amount intake was significantly more frequent in the above treatment line group (p<0.01). Hospital APAP analysis services were available in six EMCs (3/38 regional and 3/68 local). The hospital blood APAP level reporting intervals were shorter than outside-hospital laboratory services (p<0.01, regional 7.0±3.0 vs. 40.6±27.5, local 5.3±3.1 vs. 57.9±45.1 hours). The NMC toxicological laboratory reporting interval was shorter than the other outside-hospital laboratories (p<0.01, regional 5.7±0.6 vs. 50.2±22.7 local 7.5±3.0 vs. 70.5±41.5 hours). Conclusion: Over the treatment line group, toxic amount intake was significantly more frequent. Only six of 106 EMCs have their own APAP analysis service in their hospitals.

• 한국환경생태학회지
• /
• 제34권1호
• /
• pp.72-84
• /
• 2020

본 연구의 목적은 난임 여성을 위한 산림치유 프로그램 개발의 기초자료를 제공하는 데 있다. 본 연구는 탐색적 연구로 난임 여성의 정서적 특성과 정서적 특성에 따른 산림치유 요구도가 무엇인지 밝혀내어 산림치유 프로그램 개발과 운영을 위한 기초 자료를 제공할 것이다. 본 연구는 서울 소재 난임 전문병원에 내왕하는 난임 여성 200명을 대상으로 난임 여성의 정서적 특성과 산림치유 프로그램 요구도에 대한 33항목을 설문한 조사연구이다. 자료 분석은 SPSS 21.0 프로그램을 이용하여 난임여성의 정서적 특성과 산림치유 프로그램에 대한 요구 사이의 상관관계와 중요도를 파악하고자 빈도분석과 교차분석, 일원분산분석을 진행하였다. 난임 여성들의 정서적 특성은 임신에 대한 압박감, 불안 및 두려움, 우울, 절망감, 무기력, 외로움, 슬픔, 수치심 및 죄책감, 조급함과 답답함, 분노 및 과민함 등으로 나타났다. 난임 여성의 임신에 대한 압박감, 우울, 절망감, 무기력, 외로움, 슬픔과 분노와 과민함, 불안 및 두려움이 높게 나타났다. 난임 여성의 정서적 특성에 따른 산림치유 프로그램 요구도 차이를 알 수 있었다. 임신에 대한 압박감과 수치심 및 죄책감에 따라서 난임 부부 산림치유 프로그램의 운영 형태가 유의한 차이가 있는 것으로 나타났다. 불안과 두려움에 따라서 프로그램 참여 경험이 유의한 차이가 나타났고, 우울, 절망감, 무기력, 외로움, 슬픔에 따라서는 산림치유 프로그램에 참여하지 못하는 이유에 유의한 차이가 있는 것으로 나타났다. 조급함과 답답함에 따라서는 희망하는 산림치유 프로그램 동반 참여자에 대해 유의한 차이가 있는 것으로 나타났다. 분노와 과민함에 따라서 산림치유 프로그램 참여경험 및 난임 여성을 위한 산림치유 프로그램을 통한 자조모임의 효과에 대해 유의한 차이가 있는 것으로 나타났다. 본 연구의 분석 결과가 난임 여성의 심신건강 증진을 위한 산림치유 프로그램을 개발하는 데 기초자료로 활용되기를 기대한다.

• 정신신체의학
• /
• 제25권2호
• /
• pp.185-192
• /
• 2017

연구목적 최근 남성에서 섭식장애의 유병률이 증가되고 있다. 본 연구에서는 국내 남성 섭식장애 환자의 임상적 특징을 알아보고자 하였다. 방 법 본 연구는 2010년 3월부터 2016년 11월까지 인제대학교 서울백병원 섭식장애 클리닉에 내원한 남성 환자 32명과 대조군인 여성 환자 75명을 대상으로 하였다. 남성 및 여성 환자 간 섭식병리 및 공존정신병리를 비교하였으며, 면담도구로는 섭식장애검사(Eating disorders examination)를 사용하였으며, 설문평가로는 벡 우울 척도(Beck Depression Inventory)와 스필버그 상태-특성 불안 척도(Spielberger State and Trait Anxiety Inventory)를 사용하였고, 체중관련 변수들을 조사하였다. 남성 환자 군을 대상으로 과거 체중감량의 정도와 섭식장애 병리 간의 연관성을 탐색하였다. 결 과 남녀 환자 간 내원 연령, 발병 연령, 이환 기간, 내원 시의 체질량지수는 유의한 차이가 없었다. 남성 섭식장애 환자에서 여성 환자들에 비하여 병전 과체중 및 비만의 기왕력이 더 높게 나타났다(${\chi}^2=4.692$, p=0.03). 남녀 간 동반되는 불안 증상의 정도는 차이가 없었으나, 남성 환자군에서 우울 증상의 정도가 낮았다(d=0.63). 남성 환자들에서 과거 체중감량 정도와 현재의 섭식장애 병리간 관련 있었다. 결 론 본 연구는 한국인 남성을 대상으로 섭식장애의 임상적 특징을 탐색한 첫 연구라는 데 큰 의의가 있다. 본 연구결과는 남성 섭식장애 환자들의 치료에 대한 접근을 높이고 예방계획을 수립하는 데 중요한 단서가 될 수 있을 것이다.

• 여성건강간호학회지
• /
• 제8권4호
• /
• pp.583-594
• /
• 2002

The purpose of this study was to perform the fetal education effectively for the delivered woman and her husband. This study was conducted by the questionnaire survey on 199 delivered women and their 171 husbands at several hospitals located in Seoul and Kyonggi Province from February 28 to March 26, 2002. The contents of questionnaire included the purposes, the cognition and the practice of fetal education. The SAS program was used for the statistical analysis of the data. The character of subject was analyzed by the percentage. The difference between the cognition and practice of fetal education was analyzed by t-test, ANOVA, Wilcoxon rank sum test. The factor analysis affected on the practice of fetal education was adopted by Multiple regression. The results were as follows; 1. In the purpose of fetal education, the well- balanced emotion showed the highest mark. The cognition of fetal education(woman:$4.39{\pm}0.52$, husband:$3.88{\pm}0.70$) and the practice (woman:$3.88{\pm}0.60$, husband:$3.83{\pm}0.70$) showed the relatively high mark, but the score of cognition showed higher than that of practice. 2. In the comparison of the cognition between the delivered woman and the husband for the fetal education the item of the mental or health state would affect unborn baby, which occupied the highest mark in both woman and the husband(woman:$4.81{\pm}0.44$, husband:$4.81{\pm}0.50$). But they were prohibited to eat the deformed food, which showed the lowest mark(woman:$3.19{\pm}1.12$, husband:$3.21{\pm}1.29$). 3. In the comparison of the practice for the fetal education between the delivered woman and the husband, the practice for the healthy baby showed the highest mark in woman ($4.51{\pm}0.71$), which had a statistically significant difference(P=0.025), compared with that of the husband($4.13{\pm}0.99$). 4. In the comparison of cognition and practice for the fetal education, the general character was associated with the duration of marriage, the satisfaction with marriage and the support of husband on pregnancy. The mark was associated with the age of woman, the level of education and the first birth. 5. The significant factors influencing on the practice for the fetal education were connected with the cognition of fetal education, age, satisfaction with marriage, the support of husband on pregnancy, the type of family, the experience of delivery and the state of health during the period of pregnancy. etc. In conclusion, it is indicated to make effort for transforming and developing the traditional fetal education in accordance with the modern fetal education. And it is suggested that the fetal education might be recognized by all members of family, and the importance of husband's role for the fetal education should be informed as well as that of woman's.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4455-4458
• /
• 2014

Breast cancer is a serious and potentially lethal multi-factor disease among 40-50 aged women in both developed and developing countries. Also, various studies have pointed to roles of neurotransmitters like serotonin in development of cancers, through action on various types of receptors. This study was conducted to evaluate serotonin receptor (5HT2AR and 5HT3AR) genes expression in peripheral blood mononuclear cells (PBMCs) of breast cancer patients in comparison with the healthy people and in the MCF7 cell line. Peripheral blood samples were obtained from 30 patients and 30 healthy individuals. Total RNA was extracted from PBMCs and MCF-7 cells. and 5HT2AR and 5HT3AR were detected by RT-PCR techniques. Finally, serotonin receptor gene expression variation in breast cancer patients and MCF-7 cells were determined by real time-PCR. This latter indicated significant promotion in expression of 5HT3AR and 5HT2AR in PBMCs in breast cancer patients but expression of 5HT2AR in the MCF-7 cell line was significantly decreased. In conclusion, after performing complimentary tests, determine of gene expression changes in serotonin receptors (5HT2AR and 5HT3AR) may be useful as a new approach in treatment of breast cancer based on use of antagonists.

• Neonatal Medicine
• /
• 제25권1호
• /
• pp.7-15
• /
• 2018

We need to understand the outcomes into adulthood for survivors born either extremely low birthweight (ELBW; <1,000 g) or extremely preterm (EP; <28 weeks' gestational age), particularly their blood pressure and cardiovascular metabolic status,respiratory function, growth, psychological and mental health performance, and functional outcomes. Blood pressure is higher in late adolescence and early adulthood in ELBW/EP survivors compared with controls. In some studies, expreterm survivors have higher insulin and blood lipid concentrations than controls, which may also increase their risk for later cardiovascular disease. ELBW/EP survivors have more expiratory airflow obstruction than do controls. Those who had bronchopulmonary dysplasia (BPD) in the newborn period have even worse lung function than those who did not have BPD. As a group, they are unlikely to achieve their full lung growth potential, which means that more of them are likely to develop chronic obstructive airway disease in later life. Although they are smaller than term born controls, their weight gradually rises and ultimately reaches a mean z-score close to zero in late adolescence, and they ultimately attain a height z-score close to their mid-parental height z-score. On average, ex-preterm survivors have intelligence quotient (IQ) scores and performance on tests of academic achievement approximately 2/3 SD lower than do controls, and they also perform less well on tests of attention and executive function. They have similar high rates of anxiety and depression symptoms in late adolescence as do controls. They are, however, over-represented in population registries for rarer disorders such as schizophrenia and Autism Spectrum Disorder. In cohort studies, ex-preterm survivors mostly report good quality of life and participation in daily activities, and they report good levels of self-esteem. In population studies, they require higher levels of economic assistance, such as disability pensions, they do not achieve education levels as high as controls, fewer are married, and their rates of reproduction are lower, at least in early adulthood. Survivors born ELBW/EP will present more and more to health carers in adulthood, as they survive in larger numbers.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권23호
• /
• pp.10339-10343
• /
• 2015

Breast cancer is the most common cancer among females worldwide and a most prevalent malignancy in Iranian women. Chronic stress may make an important contribution to cancer, especially in the breast. Numerous studies showed roles of neurotransmitters in the occurrence and progression of cancers which are mediated by their various types of receptors. This study was conducted to evaluate alterations in the expression profile of dopamine receptor genes in peripheral blood mononuclear cells (PBMC) as stress factors in breast cancer patients and the human breast cancer cell line (MCF-7). Peripheral blood samples were obtained from 30 patients and 30 healthy individuals. Total mRNA was extracted from PBMC and MCF-7 cells and RT-PCR was performed to confirm the presence of five dopamine receptors (DRD1-DRD5). Expression changes of dopamine receptor genes were evaluated by real time PCR. We observed that DRD2-DRD4 in PBMCs of breast cancer patients were increased compared to healthy individuals. In addition, all dopamine receptor subtypes but DRD1 were expressed in MCF-7 cells. Therefore, alterations of these receptors as stress factors should be assessed for selecting appropriate drugs such as D2-like agonists for treatment of breast cancer after performing complimentary tests. Determining the expression profile of dopamine receptor genes thus seems promising.

• 가정의학회지
• /
• 제39권6호
• /
• pp.340-346
• /
• 2018

Background: Several studies have revealed the frequency of family mealtimes to be inversely associated with depressive symptoms in adolescents. However, there have been few studies in older populations. This cross-sectional study investigated the association between family mealtime frequency and depressive symptoms in elderly Koreans. Methods: This study analyzed 4,959 elderly men and women (aged 65 years or older) who participated in the Korea National Health and Nutrition Examination Survey. Self-administered questionnaires were used to assess depressive status, family mealtime frequency, and covariates. Multiple logistic regression analysis was performed to evaluate the association using the eating alone group as a reference. Results: After adjusting for all covariates, participants who had family meals 3 times a day had fewer depressive symptoms than the eating alone group; adjusted odds ratios (ORs) (95% confidence intervals [CIs]) were 0.72 (0.58-0.89) for point depressiveness/anxiety and 0.73 (0.56-0.94) for depressiveness lasting for at least 2 weeks. In suicidal ideation, the OR (95% CI) of eating with family twice a day was significant after full adjusting for covariates at 0.67 (0.50-0.88). Conclusion: Family mealtimes were closely associated with depressive symptoms in elderly Koreans, which suggests that maintaining intrafamilial bonding is important for mental health in an older population.

• 대한물리의학회지
• /
• 제14권1호
• /
• pp.75-89
• /
• 2019

PURPOSE: This study measured the impact of a 12-week fall-prevention exercise program on balance, ambulatory ability, lower limb strength, and psychosocial characteristics in older adults diagnosed with dementia. METHODS: The participants comprised 31 older adults (9 men, 22 women) diagnosed with Alzheimer's or vascular dementia at a long-term care hospital located in Gunsan City. A fall-prevention exercise program was provided to the experimental group, while the control group was only provided with instruction and materials related to the fall-prevention exercise program. The participants were evaluated before the intervention, 6 weeks after the intervention, and 12 weeks after the intervention on static and dynamic balance abilities (using Timed Up and Go test: TUG, Tinetti-balance scale, one-leg standing test: OLS), gait (Tinetti-balance scale, 6-minute walk test: 6MWT), lower limb strength (sit to stand test; STS), and psychosocial characteristics (Short Form 36 Health Survey-Korean version, Korean Mini-Mental State Exam). RESULTS: An independent samples t-test and repeated measures analysis of variance were used for the statistical analysis. There were statistically significant improvements after the intervention (p<.05) in dynamic balance abilities (TUG and OLS using the left foot), gait (6MWT), and lower limb strength (STS) for the experimental group, but not for the control group. No difference was seen in psychosocial characteristics. CONCLUSION: Older adults with dementia who participated in the fall-prevention exercise program showed significant improvements in their static and dynamic balance abilities, lower limb strength, and ambulatory ability after the intervention.

• 재활간호학회지
• /
• 제4권1호
• /
• pp.7-19
• /
• 2001

The Objectives of this research is to determine the effect of aerobic exercise program on health status and physical fitness in patients after the stem cell transplantation. This research design is one-group pretest-post test design. Sixteen subjects were selected from one university hospital in Seoul for the study, they was carried out aerobic exercise three to five times a week for 12 weeks. The period of data collection was from February to July, 2000. The collected data was analysed by descriptive analysis, paired t-test, content analysis SAS program was used for the statistical analysis. The results are as follows : 1. There was a significant improvement in the Physical functioning, Vitality and Reported change (t=2.39, p=0.03; t=2.35, p=0.03; t=2.58, p=0.02) but no change was observed in the Role physical, General health perception, Bodily pain, Social functioning, Role emotional and Mental health. 2. There was a significant improvement in the physical fitness (higher VO2 max, t=2.43, p=0.02; lower systolic pressure, t=-4.09, p=0.001; lower diastolic pressure, t=-3.43, p=0.002; lower pulse rate, t=-3.43, p=0.004; higher muscle sustaining power, t=2.79, p=0.015; higher muscle power, t=5.18 p=0.000; higher power of beginning, t=5.55, p=0.001; higher the sense of equilibrium, t=3.57, p=0.003; higher Hemoglobin, t=5.92, p=0.000; higher Hematocrit, t=5.38, p=0.000). Therefore, this study will provide a theoretical back ground for patients after stem cell transplantation to understand the importance of physical exercise and maintain physical exercise; and for other researches to refer to the results for exercise protocol of rehabilitation program.