• 한국정보과학회논문지:소프트웨어및응용
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• 제33권5호
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• pp.460-469
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• 2006

이기종의 분산시스템들을 통합하여 기업 환경에 적용할 수 있도록 여러 다양한 연구들과 시도들이 이루어지고 있다. 그러나 웹서비스가 갖는 특별한 구조 즉, 서비스 제공자, 서비스 요청자, 그리고 서비스 저장소의 세 역할을 갖기 때문에, 웹서비스 기술에 기존의 시스템 개발 방법론을 직접 적용하기는 어렵다. M4WSD(Method for Wes Services Development)는 웹서비스 개발 프로세스 모델로서, 요구사항 분석 단계에서 유도되는 유스케이스 모델을 기반으로 하는 웹 서비스 개발 절차 및 가이드라인을 포함하고 있다. 본 논문에서는 각 서비스를 구현하기 위하여 주요 구현 전략을 어떻게 결정하는지에 초점을 맞춘다. 본 논문에서 제시하는 평가 가이드라인은 구현 전략을 결정하는 문제를 구조화할 수 있도록 한다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.963-966
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• 2008

본 연구에서는 최근까지 유사관측을 수행하고 있는 금강본류 하도구간의 금남$\sim$공주 지점을 대상으로 하였다. 분석을 위하여 이 지점의 총유사량 산정에 영향을 미치는 부유사량 관측 및 수위, 유량과 같은 하천 흐름 등에 관한 과거의 자료를 수집 정리 하였다. 본 연구에서 적용하고자 하는 교량의 교각에 대한 기하학적 형상은 원형, 정사각형, 정팔각형, 장방형으로 하였으며 분석 모형은 SED2D-WES 모형을 이용하여 유역에 대한 교각의 형상이 미치는 영향에 대하여 연구 하였다. 그 결과 지름이 6m, 경간장 57m인 원형교각의 경우 교각에서 약 14.3m 떨어진 곳에서 최고 유속 0.75m/s가 발생되었으며, $6{\sim}6m$의 정사각형교각의 경우 교각으로부터 약 15.8m떨어진 곳에서 0.68m/s의 최대 유속이 발생하고 $6{\sim}6m$ 정팔각형교각의 경우 교각으로부터 약 16.2m떨어진 곳에서 0.65m/s의 최대유속이 발생하고, 마지막으로 $3{\sim}6m$ 장방형교각의 경우 교각으로부터 약 21m 떨어진 구간에서 0.63m/s의 최고 유속이 발생하는 것으로 나타났다. 대상유역의 길이가 길고, 유속이 낮으므로 유출지점까지 흘러내려가는 유사량보다 하천내에 유입된 유사가 그대로 퇴적되는 경우가 많아 24시간 분석결과 하상변동량은 퇴적량과 침식량을 합하여 약 0.22%정도 변동되는 것으로 나타났으며, 교각형상에 따른 하상변동특성으로 원형교각의 경우 세굴이 일어나는 지점은 교각에서 약 16.88m떨어진 지점까지 하상변동이 일어났으며, 정사각형 교각의 경우 교각에서 약 10.96m떨어진 지점까지, 정팔각형 교각의 경우 교각에서 약 6.32m떨어진 지점까지, 장방형 교각의 경우 교각에서 약 18.23m떨어진 지점까지 하상변동이 나타남을 알 수 있었다.

• 한국환경과학회지
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• 제18권2호
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• pp.221-230
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• 2009

In this study, a river basin with a lot of measured data such as water level, flow rate, current speed, and sediment rate from the past to now was selected and geometrical shape of a pier was re-analyzed, in order to study the effects of the flow around the pier area as well as the riverbed alternation characteristics. A finite element mesh of the entire river was prepared, and via parameter revision, the section that the pier has influence on was decided, to analyze the shape of the pier using RMA-2 and SED2D-WES models. With regards to the section that the pier has influence on, analysis was done on the four pier shapes, namely circle, square, rectangle, and octagon. The results showed that the shape with the least influence around the pier around is the octagon, followed by circle, rectangle, and square, showing the different geometrical effects that the shapes have on the pier. Furthermore, it was shown that the distribution of sediment concentration had effect from about (+) 110 m of the upstream to about (-) 130 m of the downstream, from the pier installation point. Also, it was shown after analyzing drag forces for different sediment particle distributions that the shape with the greatest drag is the octagon, followed by circle, square, and rectangle.

• 복식
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• 제37권
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• pp.71-88
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• 1998

This study will analyze the aesthetic qual-ities revealed in the work of Vivienne Wes-twood in order to gain an understanding of the development process and uniqueness of modern avant-garde fashion. Westwood gained worldwide recognition in the 1970s as the Punk movement emerged in London. Although her works have often been described as decadent and anti-establishment, her anarchic view of fashion has had a considerable influence on other designers, both in England and around the world. Vivienne Westwood's works can be divided into three periods. In the first period(1971∼78). Westwood design demonstrated elements which were variations of the subcultural Punk style. The noteworthy designs of this period included ripped T-shirts, bondage clothes, and fetishist accoutrements. In the second period(1979∼83), her designs expressed elements from ethnic and primitive tribal societies through the 'Pirate', 'Savages', 'Buffalo Girls', 'Witches' collections, which inspired New Romanticism movement. In the third period (1985∼ ), through works such as 'Mini-Crini'collection, her works identified elements from the old west and used materials such as crinoline and Harris tweed and contemporized them by rearranging the innovative technique. In the end the news synthesis helped formulate new ideas. The aesthetic qualities in Vivienne Wes-twood's works can bed identified with the following themes : Punkature, Erotic Intelligent-sia, Anarchic Collage. First, within Punkature, Westwood's ideas are at the forefront as her impact on the cut of clothes and creative detailing have been considerable. Also, while her ideas can be extreme, her clothes are wear-able, resulting in the synthesis of Punk and couture. Second, as Erotic Intelligentsia, Vivienne Westwood does not present sexuality as a straight forward attribute that fashion so often tends to do, but instead as a matter for inquiry, exploration and debate. She asserts that sexuality is always an interplay between the polarities of masculine and feminine, of dress and undress. Third, as Anarchic Collage, she has taken, juxtaposed, and transformed objects and symbols from dominant culture, like every modern subversive movement from Dada to Punk. She has continued this form of anarchic collage, mixing styles from various times and places, taking them out of their traditional context. From thiss viewpoint, Vivienne Westwood's works can be considered to be made up of past themes merged with is contemporary. The usage of contrasting elements such as Punk and couture to communicate her ideas visually or technically.

• Physical Therapy Rehabilitation Science
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• 제6권2호
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• pp.77-82
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• 2017

Objective: Swimming and water-based exercise (WE) programs can provide vigorous physical activity in a fun and a motivating environment. The properties of water, may make it easier for children with cerebral palsy (CP) to move and to participate in an WE program. The aims of this study was to evaluate the effect of WEs on postural control in children with spastic CP. Design: Quasi-experimental design (one group pretest-posttest design). Methods: Twenty preschoolers with spastic CP participated in this study. Prior to the application, sufficient warm-up training was performed to allow the subjects to adapt to the water. Afterwards, three different types of underwater leg exercises for the flexor, extensor, and adductor/abductor of muscles of the lower limb were performed. The WE program lasted during 8 weeks, with one-40 minute sessions per week (8 training session). The usual care was performed during the training session. The Korean-trunk control measurement scale (K-TCMS) and weight distribution variability (difference of both Fz) were measured before and after training session. Results: According to the results, the K-TCMS scores of the three sub-levels, including static sitting, dynamic sitting, and dynamic reaching, was significantly increased after the training session (p<0.05). Also, the weight distribution variability was significantly decreased after 8 weeks (p<0.05). Conclusions: We suggest that WEs may improve the postural control ability in children with spastic CP. Furthermore, we support the need for additional research on the effect of WE on gait or activity of daily living performance with a control group included.

• 한국지형학회지
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• 제24권3호
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• pp.105-118
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• 2017

The debris slope landforms which are existent in Korean mountains is generally on the steep slopes and mostly covered by vegetation, it is difficult to investigate the landform. Therefore a scientific method is required to come up with an effective field investigation plan. For this purpose, the use of Remote Sensing and GIS technologies for a spatial analysis is essential. This study has extracted the potential area of debrisslope landform formation using Fuzzy set and Bayesian Predictive Discriminate Model as mathematical data integration methods. The first step was to obtain information about debris locations and their related factors. This information was verified through field investigation and then used to build a database. In the second step, the map that zoning the study area based on the degree of debris formation possibility was generated using two modeling methods, and then cross validation technique was applied. In order to quantitatively analyze the accuracy of two modeling methods, the calculated potential rate of debrisformation within the study area was evaluated by plotting SRC(Success Rate Curve) and calculating AUC(Area Under the Curve). As a result, the prediction accuracy of Fuzzy set model wes 83.1% and Bayesian Predictive Discriminate Model wes 84.9%. It showed that two models are accurate and reliable and can contribute to efficient field investigation and debris landform management.

• Genes and Genomics
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• 제40권12호
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• pp.1269-1277
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• 2018

Bcl2-associated athanogene 3 (BAG3) mutations have been reported to cause the myofibrillar myopathy (MFM) which shows progressive limb muscle weakness, respiratory failure, and cardiomyopathy. Myopathy patients with BAG3 mutation are very rare. We described a patient showing atypical phenotypes. We aimed to find the genetic cause of Korean patients with sensory motor polyneuropathy, myopathy and rigid spine. We performed whole exome sequencing (WES) with 423 patients with sensory motor polyneuropathy. We found BAG3 mutation in one patient with neuropathy, myopathy and rigid spine syndrome, and performed electrophysiological study, whole body MRI and muscle biopsy on the patient. A de novo heterozygous p.Pro209Leu (c.626C>T) mutation in BAG3 was identified in a female myopathy. She first noticed a gait disturbance and spinal rigidity at the age of 11, and serum creatine kinase levels were elevated ninefolds than normal. She showed an axonal sensory-motor polyneuropathy like Charcot-Marie-Tooth disease (CMT), myopathy, rigid spine and respiratory dysfunction; however, she did not show any cardiomyopathy, which is a common symptom in BAG3 mutation. Lower limb MRI and whole spine MRI showed bilateral symmetric fatty atrophy of muscles at the lower limb and paraspinal muscles. When we track traceable MRI 1 year later, the muscle damage progressed slowly. As far as our knowledge, this is the first Korean patient with BAG3 mutation. We described a BAG3 mutation patient with atypical phenotype of CMT and myopathy, and those are expected to broaden the clinical spectrum of the disease and help to diagnose it.

• Clinical and Experimental Pediatrics
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• 제62권5호
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• pp.193-197
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• 2019

Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (${\alpha}3$, ${\alpha}4$, and ${\alpha}5$). ATS is characterized by persistent microscopic hematuria that starts during infancy, eventually leading to either progressive nephritis or end-stage renal disease. There are 3 known genetic forms of ATS, namely X-linked ATS, autosomal recessive ATS, and autosomal dominant ATS. About 80% of patients with ATS have X-linked ATS, which is caused by mutations in the type IV collagen ${\alpha}5$ chain gene, COL4A5. Although an 80% mutation detection rate is observed in men with X-linked ATS, some difficulties do exist in the genetic diagnosis of ATS. Most mutations are point mutations without hotspots in the COL4A3, COL4A4, and COL4A5 genes. Further, there are insufficient data on the detection of COL4A3 and COL4A4 mutations for their comparison between patients with autosomal recessive or dominant ATS. Therefore, diagnosis of ATS in female patients with no apparent family history can be challenging. Therefore, in this study, we used whole-exome sequencing (WES) to identify mutations in type IV collagen in 2 girls with glomerular basement membrane structural changes suspected to be associated with ATS; these patients had no relevant family history. Our results revealed de novo c.4688G>A (p.Arg1563Gln) and c.2714G>A (p.Gly905Asp) mutations in COL4A5. Therefore, we suggest that WES is an effective approach to obtain genetic information in ATS, particularly in female patients without a relevant family history, to detect unexpected DNA variations.

• 대한유전성대사질환학회지
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• 제20권2호
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• pp.50-54
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• 2020

Vici 증후군은 18q12.3 염색체에 위치하는 EPG5 유전자의 돌연변이로 인해 발생하는 상 염색체 열성 증후군이다. EPG5 유전자는 리소좀 형성에 관여하는 자가 포식 경로의 중요한 조절자를 암호화하므로 이에 대한 돌연변이로 인해 다양한 임상증상을 나타나게 된다. 주요한 임상증상으로는 뇌량 무형성, 백색증, 백내장, 심근 병증, 중증 정신 운동 지체, 발작, 면역 결핍 등이 있으며 다양한 임상증상을 나타내는 만큼 다른 질환들과 임상적으로 구분하기가 어렵다. 저자들은 Vici 증후군으로 진단된 3세 남자 환아의 증례를 보고하고자 한다. 환아는 생후 2개월 경 근긴장 저하와 수유 곤란을 주소로 내원하였으며 이후 Vici 증후군에서 나타나는 특징적인 임상 증상들을 나타내었다. 임상증상들의 감별 진단을 위해 시행한 Whole-exome sequencing (WES) 결과, EPG5 유전자에서 c.2254 C>T (p.Gln752Ter)와 c.5511-5518+2 del TATGCAAAGT 새로운 변이가 이형접합체로 확인되었다. Vici 증후군과 같이 임상적으로 구분이 어려우며 다양한 신체기관에 걸쳐 영향을 미치는 질환의 진단 시에는 Whole-exome sequencing (WES)가 유용하게 사용될 수 있다. 이 증례는 한국에서 확인된 첫 Vici 증후군 case로써 의의가 있다.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2006년도 추계학술발표대회 논문집
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• pp.144-148
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• 2006

Kitchen space is one of the most dangerous places for the elderly. Modification of kitchen space for improving safety and independence for older residents is very important factor for aging -in-place. The purpose of this study wes to identify the current situation and modification of kitchen space by elderly-headed household. The sample included 108 respondents over the age 65 who consisted of elderly-couple or single person household with homeownership in Seoul. The data were analyzed by descriptive statistics. Based on the findings of the study, the present incidence and recognition of future need in kitchen modification were identified. Changes in kitchen space made tended to be nonstructural or relatively inexpensive items. In conclusion, this study suggests several ideas for improving current physical problems of kitchen space to support daily living of older residents.