• Korean Journal of Biological Psychiatry
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• v.10 no.1
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• pp.3-19
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• 2003

The use of atypical antipsychotics is limited by occurrence of adverse reactions such as weight gain, despite of their benefits. This article provides a comprehensive review and discussion of the most significant findings regarding obesity-related pathways and integrates these with the known mechanism of atypical antipsychotic action. The focus of this article is primarily on the genetics of obesity related pathways that may be disrupted by atypical antipsychotics. This review also discussed weight gain, hyperglycemia or occurrence of diabetes while being treated with atypical antipsychotics from the point of view of pharmacogenetics. Pharmacogenetic research seeks to uncover genetic factors that will help clinicians identify the best treatment strategies for their patients. It will aid clinically in the prediction of response and side effects, such as antipsychotic-induced weight gain, and minimize the current "trial and error" approach to prescribing in the near future. This article also presents the genetics of both central and peripheral pathways putatively involved in antipsychotic-induced weight gain while providing a comprehensive review of the obesity literature. This article also review obesity related candidate molecules which may be disrupted during atypical antipsychotic drug treatment.

• Asian-Australasian Journal of Animal Sciences
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• v.6 no.1
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• pp.91-97
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• 1993

This experiment was carried out to examine the effects of urea-treated rice straw feeding on the growth performance of crossbred Holstein heifers under different feeding conditions. In the first experiment, the animals were given diets having 2 levels of TDN and CP and 3 levels of crude fiber (22, 30 and 36%) which were formulated with urea-treated rice straw and concentrates. Daily weight gain of heifers was not different between 22% and 30% CF diets, but the reduction of TDN or CP level to 90% of the requirements decreased the weight gain. Fiber content of 36% also reduced the body weight gain. The reduction of TDN significantly reduced DM intake and increased feed conversion ratio. Feed cost per kg weight gain was significantly increased by an increase in CF to 36%. In the second experiment, separate feeding and total mixing feeding were compared. There were no significant differences between the two feeding systems in body weight gain although the possibility of superiority in SF to TMF remained. DM intake was not affected by the feeding system, but 30% CF diet gave higher DM intake. Feed cost per kg weight gain was lower in the 30% CF diet.

• Journal of Biosystems Engineering
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• v.26 no.4
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• pp.371-378
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• 2001

This research devoted to develop an incubator that could make an optimum environment condition according to days of age for suckling pigs to decrease the mortality and improve the rate of the weight gain of the suckling pigs. Results obtained from this research summarized as follows: 1. Several experiments were carried out at the farm to find the effect of incubator developed for suckling pigs on weight gain by season. The total average gain of the weight of the treatment group was around 6∼22kg, and 6∼23kg higher than control group at the first experiment (April 19), at the second (July 30), and at the third (September 23), year of 2000 experiment, respectively. There were no significant differences ($\alpha$=5%) of the total weight gain among treatment groups. There was, however, a significant difference ($\alpha$=5%) of the total weight gain between the control and treatment groups and it was considered to be that the incubator had efficiency for weight gain of the suckling pigs. 2. The survival rate of the control group was 87% in the total sample number of 92, meanwhile, which of the experiment group was 98% in the total sample number of 50 suckling pigs. 3. Finally, economic analysis was executed for suckling pigs based on a farm size of breeding 500 sows. The results showed that a break-even point was around 9 months and the annual profit of ￦52,265,694 was expected after the break-even point.

• Journal of Korean Biological Nursing Science
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• v.21 no.3
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• pp.169-177
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• 2019

Purpose: The purpose of this paper was to identify blood pressure, interdialytic weight gain, thirst and intradialytic discomfort in subjects after applying individual low-sodium dialysis fluid (1,2,3 mEq/L) to hemodialysis patients for 12 weeks. Methods: This study was a non-equivalent pre-post design. For 12 weeks, dialysate concentration was maintained at 1 mEq/L or 2 mEq/L or 3 mEq/L based on average sodium concentration of each individual, and the difference was compared after applying individually. Results: Change in blood pressure significantly decreased in the group where in pre-hemodialysis systolic pressure decreased the gradient of sodium concentration in serum sodium and dialysis solution by 2mEq/L. Interdialytic weight gain, and thirst showed significant decrease in all three groups. But in all three groups, intradialytic discomfort among dialysis showed no significant changes. Conclusion: Although application of low sodium dialysis fluid showed no change in intradialytic discomfort, lowered blood pressure, thirst, and interdialytic weight gain, which could be used for individual showing increased interdialytic weight gain and increased blood pressure. There is need for continued study on this.

• Child Health Nursing Research
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• v.5 no.3
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• pp.250-261
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• 1999

This study has been conducted on the nonequivalent control group Pretest-posttest design in quasi experimental basis and newly born premature infants from intensive care unit of G Medical University Hospital in Inchon Metropolitan were selected in two groups of 21 infants each. The first group for experimental and the other for control. Data has been collected form October 30, 1997 to August 29, 1998. For the experimental group tactile and kinesthetic stimulation was applied 2 times a day for 10 days(10:00～ll:00 hours in the morning and 17:00～18:00 in the afternoon). As, a weight weighing instrument, electronic indicator scale(Cas Co. korea) was used. Collected data were analyzed with the SAS program using x²-test, student t-test, repeated measures ANOVA, Pearson correlated coefficient and Stepwise multiple regression. The result were as follow. 1. As for the daily weight gain, the experimental group showed first change in weight and this group also showed higher weight in the average weight than the control group. Statistically, however. there was no significant factor between the two groups. 2. In the correlation between general characteristics and weight gain, gestation Period. apgar score, admission Period before study, N.P.O. period after birth, recovery Period to birth weight showed statistical significance negative correlation with weight gam in the experimental group than control group. 3. In the factor with affected the weight gain by general characteristics showed recovery period to birth weight and head circumference in the experimental group, control group showed recovery period to birth weight, N. P. O. period after birth. admission period before study, feeding amount, weight of study. In conclusion. the sensory stimulation in this study showed a Positive aspect through there was no statistical significance in the weight gam. Tn the correlation of general characteristics and weight gam showed statistical significance negative correlation The main factor which affected the weight gain by general characteristics showed recover period to birth weight.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.63-75
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• 2001

Objectives : Many women associate one or more of their pregnancies with the development of adult obesity. This study was designed to determine influencing factors on postpartum weight retention and whether the breast-feeding was available to weight loss in puerperium. Methods : Articles from the literature on 'postpartum weight retention' were examined. Results : These articles show that different factors were related with postpartum weight retention. This study suggests that moderate weight gain during pregnancy is important to prevent postpartum maternal obesity. Especially weight gain from 20 weeks to 36 weeks of pregnancy is important. Falling in depression and anxiety during postpartum period should be avoided and social support is also needed. Delivery at the financially secure status is also recommended. Sufficient physical activity and exercise are needed to prevent from postpartum weight retention. Weight loss with dieting and exercise during lactation don't have a bad influence on the growth of infants.

• Archives of Obesity and Metabolism
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• v.2 no.2
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• pp.54-63
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• 2023

Estrogen is crucial in regulating food intake, energy expenditure, glucose metabolism, and lipid metabolism. During menopause, the decline in estrogen levels predisposes women to weight gain, abdominal obesity, insulin resistance, type 2 diabetes, hypertension, and cardiovascular disease (CVD). Menopausal hormone therapy (MHT) prevents weight gain, improves lipid metabolism by lowering low-density lipoprotein cholesterol while raising high-density lipoprotein cholesterol, and delays the onset of type 2 diabetes in menopausal women. The effect of MHT on CVD in menopausal women remains controversial. The Women's Health Initiative study was terminated prematurely after it revealed that hormone administration increased the risk of myocardial infarction, stroke, and thromboembolism. However, some studies have found that MHT had no effect or decreased the risk of CVD. The inconsistent results were likely due to multiple factors, including the timing of hormone therapy initiation, duration of therapy, type and dosage, and presence or absence of CVD risk factors at the start of treatment. Despite its benefits in terms of managing weight gain and reducing the risk of type 2 diabetes, dyslipidemia, and CVD associated with obesity, it is not recommended as the primary therapy for weight loss or diabetes prevention. MHT is primarily indicated for postmenopausal women, who are likely to benefit from its potential to prevent weight gain and improve lipid metabolism.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.3
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• pp.388-394
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• 1999

Two experiments were conducted to subdivide isoleucine (exp. 1) and valine (exp. 2) requirements for maintenance from the requirements for growth of broilers aged 1 to 3 weeks. Purified diets were used, containing five graded levels of isoleucine and valine. Based on weight gain response, the isoleucine requirement for growth was 7.50 mg/g weight gain and the daily isoleucine need for maintenance (mg) was 0.044 per unit metabolic body size ($(Wg^{0.75})$). Based on the N gain response, the isoleucine requirement for growth was 0.317 mg/mg N gain and the daily isoleucine need for maintenance (mg) was 0.040 per unit metabolic body size $(Wg^{0.75})$. Based on weight gain and N gain response, the total isoleucine requirement was calculated 244 mg/day or 0.59% of the diet, 274 mg/day or 0.66% of the diet, respectively. From the relationship of weight gain and N gain, 5.07% of the retained protein was comprised of isoleucine; the reported isoleucine content of chick muscle was 4.42%. The valine requirement for growth was 9.84 mg/g weight gain and 0.36 mg/mg N gain whereas the maintenance requirement was 0.046 or 0.052 mg per unit of metabolic body size (Wgo.11. According to the model developed to estimate valine requirement, the total requirement was 319 mg/day or 0.77% of the diet, 315 mg/day or 0.76% of the diet, respectively. Previous reported valine requirements for growing chicks of 7~24 days old were in close agreement with these estimates. As a percentage of retained protein, valine was calculated to be 5.81% ; the reported valine concentration of crude protein of chicks' body including feathers was 6.72%.

• Women's Health Nursing
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• v.25 no.2
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• pp.143-153
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• 2019

Purpose: We aimed to examine the correlations between pregnancy experience and attitude regarding weight change during pregnancy. Methods: This correlative study was conducted from July 2017 to October 2017 by involving 156 primigravida women who were over pregnancy 20 weeks in Seoul and Gyeonggi-do province. Data were collected using a questionnaire, which included questions on demographic data, experience during pregnancy, and attitude regarding weight change during pregnancy. Descriptive statistics were calculated. Also, independent t-test, ANOVA, and Pearson's correlation coefficients were used for data analysis. Results: The mean age of the participants was 30.62 years and their score of attitude regarding weight gain during pregnancy was low. Moreover, a significant correlation was found between the pregnancy experience and attitude regarding weight gain during pregnancy in primigravida women. Conclusion: As a result of analyzing the correlation between pregnancy experience and attitude towards weight gain during pregnancy, it is apparent that attitudes toward weight change are different according to experience during pregnancy in women. Based on these results, it can be concluded that nursing intervention programs are necessitated to enhance the attitude of pregnant primigravida women towards pregnancy and weight gain.

• Journal of Nutrition and Health
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• v.56 no.3
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• pp.288-299
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• 2023

Purpose: This study aimed to assess the weight fluctuations in college students during the coronavirus disease 2019 (COVID-19) pandemic and identify lifestyle and dietary changes related to weight gain. Methods: An online survey was conducted on 270 college students from September 22 to October 26, 2021. A logistic regression analysis was performed to analyze the relationship of weight gain with the general characteristics, lifestyle, and dietary changes of the students. Results: Among the respondents, 42.9% of men and 44.7% of women reported weight gain. The main reasons given for weight gain were reduced activities due to restrictions during lockdown and diet changes, mainly relating to delivered or fast foods. Among the general characteristics and lifestyle factors poor perceived health (odds ratio [OR], 3.97, 95% confidence interval [CI], 1.98-7.96) and being underweight (OR, 0.19, 95% CI, 0.05-0.83) were significantly associated with weight gain. With respect to the diet, increased frequency of eating breakfasts (OR, 4.44, 95% CI, 1.76-11.21), decreased frequency of eating snacks (OR, 0.35, 95% CI, 0.16-0.77), decreased frequency of fruit intake (OR, 3.0, 95% CI, 1.32-6.80), increased frequency of carbonated and sweetened beverage intake (OR, 2.74, 95% CI, 1.26-5.99) and increased frequency of fast food consumption (OR, 2.32, 95% CI, 1.14-4.70) were significantly associated with weight gain. Conclusion: The COVID-19 pandemic affected weight gain and caused lifestyle and dietary changes. Specific health and nutrition management plans should be prepared for handling future epidemics of infectious diseases based on the results of surveys conducted on larger sample size.