• Food Science and Preservation
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• v.21 no.5
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• pp.727-734
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• 2014

To investigate anti-thrombosis and anti-oxidation activities of the root of Arctium lappa L (RALL), which has been used as foodstuff and oriental medicine in Korea, the ethanol extract and its subsequent organic solvent fractions of the RALL were prepared. The yield of ethanol extraction was 10.94%, and the content of total polyphenol and total sugar of ethanol extract were 5.01 and 694.53 mg/g, respectively. The fraction yields of n-hexane, ethylacetate (EA), butanol and water residue were 1.62, 0.42, 5.98 and 85.38%, respectively. In anticoagulation activity assay, the ethanol extract of RALL did not show significant changes in thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT), whereas the EA fractions showed 13 folds extended TT, PT, and aPTT respectively. Interestingly, the water residue showed strong activation effect against blood clotting factors with shortened aPTT, which might provide the evidence of coagulation agent of RALL in folk remedy. In anti-platelet aggregation assay, the activity of the ethanol extract and its fractions were comparable to that of aspirin. Especially the EA fraction showed 2-folds higher inhibitory activity than aspirin. In anti-oxidation activity assay, the EA fraction also showed strong in DPPH, ABTS and nitrite scavenging activity, and reducing power activity. The extract and fractions of RALL have ignorable hemolytic activity against human RBC up to 0.5 mg/mL concentration. Our results suggest that the EA fraction of RALL have potentials as safe and novel anti-thrombosis agent.

• Food Science and Preservation
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• v.24 no.5
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• pp.631-637
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• 2017

The physiological properties of extracts from Hizikia fusiforme with different extraction methods (hot water extraction, autoclave extraction and high pressure extraction) were investigated. The amounts of substances related to polyphenol and flavonoids contents were the highest in autoclave extract (30.51 mg/g and 4.78 mg/g, respectively). The DPPH radical scavenging activity was the highest in the autoclave extract (81.80%) at the 5 mg/mL. Autoclave extract exhibited the strongest ABTS radical scavenging activity and reducing power among the three extraction methods. However, ferrous ion chelating, TBA reactive substances and xanthine oxidase inhibition activity of high pressure extract were higher than those of the other extracts. Additionally, the tyrosinase and elastase inhibition activities of high pressure extract with a concentration of 1 mg/mL were higher than those of the other extracts. These results suggest that extracts of Hizikia fusiforme have a potential to act as functional materials, and autoclave and high pressure extractions are superior to hot water extraction for enhancement of the biological activity.

• Journal of Life Science
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• v.25 no.7
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• pp.757-764
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• 2015

The immature fruit of Rubus coreanus Miquel (bokbunja in Korean) is mainly consumed as a fruit wine due to its sour taste and low sugar content. The lees (LBW) remaining after the production of bokbunja wine are discarded as they have no specific usage. The aim of this study was to develop high-value-added biomaterials for functional foods and beauty/health products by investigating the anti-microbial, anti-oxidant, and anti-thrombosis activities of LBW using ethanol and hot water extracts and their subsequent organic solvent fractions. The ethyl acetate (EA) fraction of LBW extracts has a high polyphenol content (413–459 mg/g), and showed strong anti-microbial activity against gram-positive bacteria. The EA fraction also showed excellent radical-scavenging activity against DPPH anion, ABTS cation, and nitrite, with strong reducing power. The polyphenol-enriched EA fraction strongly inhibited thrombin, prothrombin, and blood coagulation factors. The butanol fraction showed a specific inhibition of coagulation factors, as measured in activated partial thromboplastin time assay, which is linked to intrinsic blood coagulation. The butanol fraction also showed strong inhibition of platelet aggregation, at levels comparable to aspirin. The residue of the hot-water extract, which is produced by sequential solvent fractionation of the LBW extract, showed superior inhibition against platelet aggregation when compared to aspirin. Our results suggest that the LBW, which are currently discarded, are a promising source of novel functional foods and beauty/health products.

• Membrane Journal
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• v.24 no.6
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• pp.453-462
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• 2014

Thin film composite (TFC) polyamide (PA) membranes were prepared on polyester (PET) nonwoven reinforced polysulfone supports for forward osmosis (FO) processes. PSF (polysulfone) supports were prepared via the phase inversion process from PSF casting solutions in dimethyl formamide (DMF) solvents (19 wt%) by using a PET nonwoven (thickness of $100{\mu}m$) as a mechanical reinforcing material for reverse osmosis (RO) membrane. The PSF support from 19 wt% of DMF/PSF casting solution showed sponge-like morphology and asymmetric internal structure. To reduce the internal concentration polarization in FO operation, thin ($20{\mu}m$ of thickness) nonwoven-supported PSF supports were prepared by using PSF/DMF casting solution (9~19 wt%). A desirable support structure with a highly porous sponge-like morphology were achieved from the thin nonwoven-supported PSF layer prepared with 9~12 wt% casting solution. A crosslinked aromatic polyamide layer was fabricated on top of each support to form a TFC PA membrane. The tested sample from 12 wt% of DMF/PSF casting solution presented outstanding FO performance, almost 5.5 times higher water flux (24.3 LMH) with low reverse salt flux (RDF, 1.5 GMH) compared to a thick nonwoven rainforced membrane (4.5 LMH of flux and 3.47 GMH of RSF). By reducing the thickness of the nonwoven and optimizing PSF concentration of casting solution, the morphology of the prepared membranes were changed from a dense structure to a porous sponge structure in the boundary area between nonwoven and PET support layer.

• Korean Journal of Materials Research
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• v.8 no.2
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• pp.135-140
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• 1998

Drag reduction produced by dilute solution of water soluble ionic polymer-surfactant complex under turbulent flow in a rotating disk apparatus(RDA) was investigated in this study. Three different molecular weights of polyacrylic acid(PAA) were adopted as drag reducing additives, and distilled water was used as a solvent. Experiments were undertaken to observe the dependence of drag reduction on various factors such as polymer molecular weight, molecular expansions and flexibility, rotating speed of the disk and polymer concentration. Specific considerations were put on conformational difference between surfactant and polymer, and effect of pH on ionic polymer possessing various molecular conformation through pH. The complex of ionic polymer and surfactant(Sodium Dodecyl Sulfate) behaves like a large polyelectrolyte. Surfactant changes the polymer conformation and then increases the dimension of the polymer. The radius of gyration, hydrodynamic volume and relative viscosity of the polymer-surfactant system are observed to be greater than those of polymer itself. Such surfactant-polymer complex has enhanced drag reduction properties.

• Journal of Korean Society of Environmental Engineers
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• v.37 no.1
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• pp.7-13
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• 2015

In this study, the effective treatment reducing geosmin and dosage of PAC was suggested when taste & odor compounds flow in. The removal efficiency of geosmin was evaluated with types of chlorination. In case of low geosmin concentration below 25 ng/L, removal efficiency of geosmin was estimated at 46% by combined treatment of pre and intermediate-chlorination. But, in the exclusive intermediate-chlorination treatment, removal efficiency of geosmin was increased to 57%. In the medium geosmin concentration (25~79 ng/L), removal efficiency of geosmin was estimated at 59% by combined treatment. But, in the exclusive intermediate-chlorination treatment, removal efficiency of geosmin was increased to 87%. When high geosmin concentration above 80 ng/L flows in, removal efficiency of geosmin was estimated at 69% by combined treatment. However, in the exclusive intermediate-chlorination treatment, removal efficiency of geosmin was increased to 95%. Then, the exclusive intermediate-chlorination has an important effect on removal of geosmin. After correlation of geosmin concentration and dosage of PAC was analyzed, the coefficient of determination was estimated at 0.96. And, the proper PAC dosage chart was proposed. Also, at a initial occurrence of geosmin, when the combined treatment by intermediate-chlorination and PAC was applied, particle-bound geosmin should be removed continuously. Finally, it is proved that the combined treatment was effective to remove the geosmin by threshold levels as well as to reduce the dosage of PAC.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.8
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• pp.997-1004
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• 2006

This study was performed to investigate the storage properties of emulsion-type sausage added with Glycyrrhiza uralensis and Curcula longa hot water extracts (GCHE) extracted at $10^{\circ}C$ for 35 days. The TBARS values of sausages containing 1.0 and 5.0% GCHE were lower than that of control. The bacterial count and VBN contents of all the samples were significantly increased during the storage periods, except the group with 5.0% GCHE. The redness of all the samples was lower than that of control, while yellowness of all the samples was higher than that of control. The nitrite scavenging abilities of the sausages containing 1.0 and 5.0% GCHE were higher than that of the control. It is suggested that the addition of 1.0% hot water extracts extracted from these plants may be a potential substitute for the use of nitrite to extend shelf-life of sausages.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1302-1309
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• 2003

Physicochemical and sensory characteristics of turnip pickles added with chitosan and/or beet water extract were investigated. Turnip root slices (4${\times}$1${\times}$0.5 cm) were salted with NaCl and CaCl$_2$, soaked into pickling solution, and then stored at 2$0^{\circ}C$. Throughout the whole storage periods, pH, acidity, saltiness and soluble solid content of three pickles (C, turnip pickle; CC, turnip pickle+chitosan; CBC, turnip pickle+chitosan+beet water extract) ranged to 3.1 ∼ 3.5, 1.5 ∼ 1.7%, 0.5 ∼ 0.7% and 24.5 ∼ 28.5$^{\circ}$Brix, respectively. There were no significant differences between three pickles in saltiness, anthocyanin and reducing sugar content. However, acidity and hardness of CC and CBC were higher than those of control C throughout the storage time. While Hunter's a value of CBC was higher than those of CC or C. Sensory results showed that the best edible time was the 14th day of storage, and at that time, scores of CC and CBC were higher in over-all preference (7.8 and 8.4) than those of C (6.1), and CC and CBC maintained good sensory qualities until 28th day of storage, compared to C (p<0.05).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.1
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• pp.81-87
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• 2018

The objective of this article is to provide analytical tools for the scattering of stratum corneum (SC) and to check whether the optical clearing agents (OCAs) could be applied in optics affecting the scattering reduction. Dark field images of tape striped corneocyte separates scattered light of the SC from others in vitro. Several optical clearing agents were tested to reduce the scattering. Physical properties of SC such as water contents, keratin configuration and volume after OCAs treatment were investigated by FT-IR and 3D laser microscope. Several reducing sugars, monomeric sugars, sugar alcohol, and hyaluronic acid, which were used as humectants in cosmetic field, also reduced scattering. However, unlike dehydration in optics, water penetrated into the keratin in SC and scattering was decreased at low concentration of OCAs. In that condition, the volume of corneocyte was increased and stiffness seemed to decrease. The analyzing of tape-stripped SC, showed the change of optical and physical properties of corneocyte by optical clearing agents. The hydration of SC layer by optical clearing agents decreased the scattering of corneocyte and thus improved the skin appearance and moisturizing effect, which are important benefits in the cosmetic field and could provide new possibility to develop skin care study targeting at SC.

• Journal of Korea Water Resources Association
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• v.47 no.9
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• pp.767-776
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• 2014

Changes in climate have largely increased concentrated heavy rainfall, which in turn is causing enormous damages to humans and properties. Floods are one of the most deadly and damaging natural disasters known to mankind. The flood forecasting and warning system concentrates on reducing injuries, deaths, and property damage caused by floods. Therefore, the exact relationship and the spatial variability analysis of hydrometeorological elements and characteristic factors is critical elements to reduce the uncertainty in rainfall-runoff model. In this study, grid resolution depending on the topographic factor in rainfall-runoff models presents how to respond. semi-distribution of rainfall-runoff model using the model GRM simulated and calibrated rainfall-runoff in the Gamcheon and Naeseongcheon watershed. To run the GRM model, input grid data used rainfall (two event), DEM, landuse and soil. This study selected cell size of 500 m(basic), 1 km, 2 km, 5 km, 10 km and 12 km. According to the resolution of each grid, in order to compare simulation results, the runoff hydrograph has been made and the runoff has also been simulated. As a result, runoff volume and peak discharge which simulated cell size of DEM 500 m~12 km were continuously reduced. that results showed decrease tendency. However, input grid data except for DEM have not contributed increase or decrease runoff tendency. These results showed that the more increased cell size of DEM make the more decreased slope value because of the increased horizontal distance.