• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.592-599
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• 2019

This study is to stabilize insoluble and unstable active ingredient which is Idebenone (INCI name: hydroxydecyl ubiquinone) in a multi-lamellar vesicle (MLV) and to stabilize it in the skin care cosmetics. Idebenone is good effective raw material in the treatment of Alzheimer's disease in the medical field and a powerful antioxidant in dermatology. It is well known as a substance that inhibits the formation of melanin and cleans the skin pigment. However, it did not dissolve in any solvent and it was difficult to apply in cosmetic applications. Niosome vesicle was able to develop a nano-particle by making a multi-layer of idebenone encapsulated with a nonionic surfactant, hydrogenated lecithin and glycine soja (soybean) sterols and passing it through a high pressure microfluidizer. Idebenone niosome vesicle (INV) has been developed to have the ability to dissolve transparently in water and to promote transdermal penetration. The appearance of the INV was a yellowish liquid having specific odor, and the particle size distribution of INV was about 10~80 nm. The pH was 5~8 (mean=6.8). This capsulation with idebenone was stored in a $45^{\circ}C$ incubator for 3 months and its stability was observed and quantitatively measured by HPLC. As a result, the stability of the sample encapsulated in the niosome vesicle (97.5%) was about 66.3% higher than that of the non-capsule sample of 32.5%. Idebenone 1% INV was used for the efficacy test and clinical trial evaluation as follows. The anti-oxidative activity of INV was 38.2%, which was superior to that of 12.8% tocopherol (control). The melanin-reducing effect of B16 melanoma cells was better than INV (17.4%) and Albutin (control) (9.6%). Pro-collagen synthesis rate was 128.2% for INV and 89.3% for tocopherol (control). The skin moisturizing effect was 15.5% better than the placebo sample. The elasticity effect was 9.7% better than the placebo sample. As an application field, INV containing 1% of idebenone is expected to be able to develop various functional cosmetic formulations such as skin toner, ampoule essence, cream, eye cream and sunblock cream. In addition, it is expected that this encapsulated material will be widely applicable to emulsifying agents for skin use in the pharmaceutical industry as well as the cosmetics industry.

• Journal of the Korean Society of Mineral and Energy Resources Engineers
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• v.55 no.6
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• pp.588-595
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• 2018

This study has focused on evaluation of heavy metal contamination in seepage from 23 mine waste dumping sites in Korea. Seepage samples from the sites were taken and analyzed for heavy metals. The maximum levels (mg/L) in the samples were Al 53.98, As 16.19, Cd 1.15 Cu 37.30, Fe 28.64, Mn 39.00, Ni 0.097, Pb 0.750, and Zn 80.18. Among the sites, six mines were selected as continuous monitoring sites. As results of three months' monitoring of the sites, over the water guidelines for As, Cd, Cu, Fe, Mn, Zn and Al in seepage samples were found at two abandoned Au-Ag mines, Cd, Mn, Zn and Al at two Pb-Zn mines, and As, Fe and Mn at two other Fe-W mines. Therefore, those six mines need continuous monitoring on contamination assessment of seepage due to mining activities.

• Journal of Climate Change Research
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• v.3 no.2
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• pp.129-142
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• 2012

This study was carried out to evaluate carbon footprint during unhulled rice production and to compare mitigation technologies of methane, main carbon source during rice production, Carbon footprint of unhulled rice was a sum of $CO_2$ emission of agri-materials manufacture, rice cultivation and waste treatment. It was emitted 1.40 kg $CO_2$ during unhulled rice production, its distribution was 71.1% by $CH_4$ emission of rice cultivation, 11.8% of $N_2O$ emission by nitrogen application and 7.6% of complex fertilizer manufacture. $CH_4$ emission could be mitigated by some technologies; cultivation of the early maturing rice variety emitted lower by 44.4% than the mid maturing variety, intermittent drainage of submerged water by 43.8% than the continuous flooding condition, direct seeding by 32.0% than transplanting cultivation, no-ploughing by 20.9% than ploughing cultivation. It means that LCA on Global Warming Potential and the statistical data on innovated technical practice are key tools to systemize Measurable-Reportable-Verifiable (MRV) system for carbon footprint and carbon emission trade in the farm base.

• Journal of the Korean Geotechnical Society
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• v.34 no.11
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• pp.21-31
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• 2018

Bucket foundations are widely used in offshore areas due to their various benefits such as easy and fast installations. A bucket is installed using self-weight and the hydraulic pressure difference across the lid generated by pumping out water from inside the bucket. When buckets are installed in high permeable soil such as sands, upward seepage flow occurs around the bucket tip and interior, leading to a decrease in the effective stress in the soil inside the buckets. This process reduces the penetration resistance of buckets. However, the soil inside and outside the bucket can be disturbed due to the upward seepage flow and this can change the soil properties around the bucket. Moreover, upward seepage flow can create significant soil plug heave, thereby hindering the penetration of the bucket to the target depth. Despite of these problems, soil disturbance and soil plug heave created by suction installation are not well understood. This study aims to investigate the behavior of soil during suction installation. To comprehend the phenomena of soil plug heave during installation, a series of small-scale model tests were conducted with different testing conditions. From a series of tests, the effects of tip thickness of bucket, penetration rate, and self-weight were identified. Finally, soil properties inside the bucket after installation were approximated from the measured soil plug heave.

• Journal of the Korean GEO-environmental Society
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• v.19 no.12
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• pp.41-46
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• 2018

The wireless sensor network system has the advantage of confirming the behavior of the entire facility by improving the disadvantages of conventional monitoring system. As a result, it is widely proposed as safety diagnosis and measurement of structures, water management systems, and management systems for dam structures. However, there is a lack of research that can evaluate the condition of facilities such as safety at the same time as monitoring. In this study, it is proposed a wireless sensor network system which can evaluate the behavior characteristics of facilities and evaluate the safety status for improving the technical disadvantages on conventional monitoring system. The geotechnical risk factors for the reservoir dam facility were evaluated and the limit values for the risk factors causing the failure of the facility were set. In other words, the system was set up so that the risk factors can be measured and the limit status can be evaluated immediately for each factor. In this study, numerical analysis is carried out for seepage and slope stability analysis using the typical cross section for reservoir dams. The stress-porewater coupling finite difference numerical analysis is performed for establishing the limit displacement for reservoir dam structures. It is developed a system that can estimate the time to reach the critical value by regression analysis using the measured datas.

• Korean Chemical Engineering Research
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• v.56 no.6
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• pp.890-894
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• 2018

In this study, methylene blue which is one of dye materials was introduced as active material for aqueous redox flow battery. The redox potential of methylene blue was shifted to negative direction as pH increased. The full-cell performance was evaluated by using methylene blue as the negative active material and vanadium as the positive active material with acid supporting electrolytes. The cell voltage of methylene $blue/V^{4+}$ is very low (0.45 V). In addition, the maximum solubility of methylene blue in water is only 0.12 M. Therefore, the cell test was performed with very low concentration (0.0015 M methylene blue, $0.15M\;V^{4+}$) at first time. Cut-off voltage range was 0 to 0.8 V and $1mA{\cdot}cm^{-2}$ current density was adopted during cycling. As a result, current efficiency (CE) was 99.67%, voltage efficiency (VE), 88.83% and energy efficiency (EE) was 85.87% and discharge capacity was ($0.0500Ah{\cdot}L^{-1}$) at 4 cycle. In addition, the cell test was performed with increased concentration (0.1 M methylene blue, $0.15M\;V^{4+}$) with $10mA{\cdot}cm^{-2}$ current density, leading to higher discharge capacity ($3.8122Ah{\cdot}L^{-1}$) with similar efficiency (CE=99%, VE=85%, EE=85% at 4 cycle).

• Journal of the Korea Institute of Building Construction
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• v.18 no.6
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• pp.507-515
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• 2018

The purpose of this research is to develop a slurry-type accelerator that contains various beneficial properties such as reduction of dust generation, lower alkalinity, early age strength development, etc., and uses such slurry type accelerator to produce high performance shotcrete that present excellent resistant against chloride ion penetration. In this work, shotcrete mixtures of 0.44 and 0.338 water-to-binder ratio (w/b) were produced at construction site using slurry-type accelerator. The mechanical properties and chloride ion penetration resistance of such shotcrete (including base concrete) were evaluated. According to the experimental results, the slurry-type accelerator was successfully used to produce both w/b 0.44 and 0.338 shotcretes. The 1 day and 28 day compressive strength of shotcrete were found to be closer to or higher than 10MPa and 40MPa, respectively. The w/b 0.338 shotcrete that used 40% replacement of blast furnace slag showed lower compressive strength than w/b 0.44 shotcrete without any mineral admixture at 1 day. However, the compressive strength with 40% blast furnace slag increased significantly at 28 day. Moreover, there was more than 50% increase in chloride ion penetration resistance with blast furnace slag, showing its strong potential for higher performance shotcrete application.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.6
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• pp.629-639
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• 2018

In this study, the application of the single beam echosounder and multi beam echosounder was analyzed for the Youngsan river, from the Juksanbo to the Juksan bridge, length of 840m, width 230m and area $0.16km^2$. A single beam echosounder and a multi beam echosounder are mounted on an USV (Unmanned Surface Vessel), and each data is acquired. Then, TIN (Triangular Irregular Network) is created and the grid depth of 10m intervals is extracted. The grid depth of the single beam echo sounder and the grid depth of the multi beam echo sounder were overlapped to compare the two data. As a result of analysis using 5,024 data, the mean depth difference was 0.0319m and the standard deviation was 2.4095m. The river bed shape was similar to each other. If the multi-beam echo sounder is regarded as the standard, the volume difference of the stream is $161,882m^3$. With a multi-beam echo sounder installed, the operating distance increased by approximately 55% to 4595.85m, and the operating time increased by approximately 59% to approximately 47%.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.6
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• pp.793-800
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• 2018

It is necessary to determine an optimal design frequency for establishing stable flood control against frequent flood disasters. Depending on the importance of river and regional characteristics, design return periods are suggested from at least 50 years up to 200 years for river design. However, due to the wide range of applications, it is not desirable to reflect the geographical and flood control characteristics of river. In this study, Bayes theory was applied to seven evaluation factors to determine the optimal design return period of rivers in Chungcheongnam-do; urbanization flooded area, watershed area, basin coefficient, slope, water system and stream order, range of backwater effect, abnormal rainfall occurrence frequency. The potential flood damage (PFD) capacity was estimated considering climate change and the appropriate design return period was determined by analyzing the capacity of each district. We compared the design return periods of 382 rivers in Chungcheongnam-do with the existing design return periods. The number of rivers that were upgraded from the existing return period were 65, which have relatively large flooding areas and have large PFDs. Whereas, the number of rivers that were downgraded were 169.

• Journal of Life Science
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• v.29 no.7
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• pp.779-784
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• 2019

Free radicals are known to inhibit hair vitality by damaging the cell membranes of the hair follicles. The purpose of this study was to determine the antioxidant activities and the capacity for hair loss prevention of extracts from Platycodon grandiflorum. We prepared butanol (BF) and water (WF) fractions from P. grandiflorum. DPPH and ABTS radical scavenging activities were measured to investigate the antioxidant activities of the fractions. Both fractions exhibited dose-dependent antioxidant activities for DPPH radical production, and BF and WF almost completely suppressed ABTS radical production when supplied at 10 and 100 mg/ml, respectively. We confirmed a skin regeneration effect by treating human HaCaT skin cells with a range of BF and WF concentrations for 24 and 48 hr. The extract treatments accelerated cell proliferation. We also assayed the capacity of BF and WF to suppress inflammation using RAW264.7 cells. BF dose-dependently suppressed nitrous oxide (NO) production. Treatment of human hair follicle dermal papilla cells (HFDPC) with BF and WF promoted cell proliferation after 24, 48, and 72 hr of treatment when supplied at 10, 50, 100, and $200{\mu}g/ml$. Taken together, these results confirm the possibility of using BF and WF extracts from P. grandiflorum in formulating hair loss prevention products.